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dc.contributor.authorPoise, AO
dc.contributor.authorMcManus, DP
dc.contributor.authorWeerakoon, KG
dc.contributor.authorOlveda, R
dc.contributor.authorRoss, AG
dc.contributor.authorRogers, MJ
dc.contributor.authorGordon, CA
dc.date.accessioned2020-10-01T06:41:24Z
dc.date.available2020-10-01T06:41:24Z
dc.date.issued2020
dc.identifier.issn0031-1820
dc.identifier.doi10.1017/S0031182020001547
dc.identifier.urihttp://hdl.handle.net/10072/398078
dc.description.abstractHookworms are some of the most widespread of the soil-transmitted helminths (STH) with an estimated 438.9 million people infected. Until relatively recently Ancylostoma ceylanicum was regarded as a rare cause of hookworm infection in humans, with little public health relevance. However, recent advances in molecular diagnostics have revealed a much higher prevalence of this zoonotic hookworm than previously thought, particularly in Asia. This study examined the prevalence of STH and A. ceylanicum in the municipalities of Palapag and Laoang in the Philippines utilizing real-time polymerase chain reaction (PCR) on stool samples previously collected as part of a cross-sectional survey of schistosomiasis japonica. Prevalence of hookworm in humans was high with 52.8% (n = 228/432) individuals positive for any hookworm, 34.5% (n = 149/432) infected with Necator americanus, and 29.6% (n = 128/432) with Ancylostoma spp; of these, 34 were PCR-positive for A. ceylanicum. Considering dogs, 12 (n = 33) were PCR-positive for A. ceylanicum. This is the first study to utilize molecular diagnostics to identify A. ceylanicum in the Philippines with both humans and dogs infected. Control and elimination of this zoonotic hookworm will require a multifaceted approach including chemotherapy of humans, identification of animal reservoirs, improvements in health infrastructure, and health education to help prevent infection.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherCambridge University Press (CUP)
dc.relation.ispartofjournalParasitology
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchVeterinary Sciences
dc.subject.fieldofresearchcode0605
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode0707
dc.subject.keywordsAncylostoma ceylanicum
dc.subject.keywordsAncylostoma duodenale
dc.subject.keywordsNecator americanus
dc.subject.keywordsPhilippines
dc.subject.keywordsreal-time PCR
dc.titleMolecular identification of Ancylostoma ceylanicum in the Philippines
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationPoise, AO; McManus, DP; Weerakoon, KG; Olveda, R; Ross, AG; Rogers, MJ; Gordon, CA, Molecular identification of Ancylostoma ceylanicum in the Philippines, Parasitology, 2020
dc.date.updated2020-10-01T04:32:22Z
gro.description.notepublicThis publication has been entered in Griffith Research Online as an advanced online version.
gro.hasfulltextNo Full Text
gro.griffith.authorRoss, Allen G.


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