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dc.contributor.authorSingh, B
dc.contributor.authorHayes, SC
dc.contributor.authorSpence, RR
dc.contributor.authorSteele, ML
dc.contributor.authorMillet, GY
dc.contributor.authorGergele, L
dc.date.accessioned2020-10-06T04:32:50Z
dc.date.available2020-10-06T04:32:50Z
dc.date.issued2020
dc.identifier.issn1479-5868
dc.identifier.doi10.1186/s12966-020-01021-7
dc.identifier.urihttp://hdl.handle.net/10072/398121
dc.description.abstractBackground: This meta-analysis evaluated the safety, feasibility and effect of exercise among individuals with colorectal cancer. Methods: A database search (CINAHL, Ebscohost, MEDLINE, Pubmed, ProQuest Health and Medical Complete, ProQuest Nursing, Science Direct) for randomised, controlled, exercise trials involving individuals with colorectal cancer, published before January 1, 2020 was undertaken. Safety (adverse events), feasibility (withdrawal and adherence rates) and effect data (health outcomes including quality of life, QoL) were abstracted. Risk difference (RD) and standardised mean differences (SMD) were calculated to compare safety and effects between exercise and usual care (UC). Subgroup analyses were conducted to assess whether outcomes differed by exercise mode, duration, supervision and treatment. Risk of bias was assessed using the Physiotherapy Evidence Database tool. Results: For the 19 trials included, there was no difference in adverse event risk between exercise and UC (RD = 0.00; 95% CI:-0.01, 0.01, p = 0.92). Median withdrawal rate was 12% (0-22%) and adherence was 86% (42-91%). Significant effects of exercise compared to UC were observed for QoL, fatigue, aerobic fitness, upper-body strength, depression, sleep and reduced body fat (SMD = 0.21-0.66, p < 0.05). Subgroup analyses suggested larger benefits (p < 0.05) for QoL and fatigue for supervised interventions; for QoL, aerobic fitness and reduced body fat for ≥12-week interventions; and for aerobic fitness when interventions were during chemotherapy. Conclusion: Although reporting of safety and compliance data was lacking in most trials, findings support that exercise is safe and feasible in colorectal cancer. Further, participation in mixed-mode exercise, including unsupervised exercise, leads to improvements in various health-related outcomes.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofissue1
dc.relation.ispartofjournalThe international journal of behavioral nutrition and physical activity
dc.relation.ispartofvolume17
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchSports science and exercise
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchEducation
dc.subject.fieldofresearchNutrition and dietetics
dc.subject.fieldofresearchEpidemiology
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode4207
dc.subject.fieldofresearchcode3211
dc.subject.fieldofresearchcode39
dc.subject.fieldofresearchcode3210
dc.subject.fieldofresearchcode4202
dc.subject.keywordsAerobic exercise
dc.subject.keywordsCancer
dc.subject.keywordsColon
dc.subject.keywordsColorectal
dc.subject.keywordsExercise oncology
dc.titleExercise and colorectal cancer: a systematic review and meta-analysis of exercise safety, feasibility and effectiveness
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationSingh, B; Hayes, SC; Spence, RR; Steele, ML; Millet, GY; Gergele, L, Exercise and colorectal cancer: a systematic review and meta-analysis of exercise safety, feasibility and effectiveness, The international journal of behavioral nutrition and physical activity, 2020, 17 (1)
dcterms.dateAccepted2020-09-09
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-10-06T04:19:18Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2020 The Authors. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
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gro.griffith.authorSpence, Rosa


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