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  • Disease swamps molecular signatures of genetic-environmental associations to abiotic factors in Tasmanian devil (Sarcophilus harrisii) populations

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    McCallum429522-Accepted.pdf (1.036Mb)
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    Accepted Manuscript (AM)
    Author(s)
    Fraik, Alexandra K
    Margres, Mark J
    Epstein, Brendan
    Barbosa, Soraia
    Jones, Menna
    Hendricks, Sarah
    Schonfeld, Barbara
    Stahlke, Amanda R
    Veillet, Anne
    Hamede, Rodrigo
    McCallum, Hamish
    Lopez-Contreras, Elisa
    Kallinen, Samantha J
    Hohenlohe, Paul A
    Kelley, Joanna L
    Storfer, Andrew
    Griffith University Author(s)
    McCallum, Hamish
    Year published
    2020
    Metadata
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    Abstract
    Landscape genomics studies focus on identifying candidate genes under selection via spatial variation in abiotic environmental variables, but rarely by biotic factors (i.e., disease). The Tasmanian devil (Sarcophilus harrisii) is found only on the environmentally heterogeneous island of Tasmania and is threatened with extinction by a transmissible cancer, devil facial tumor disease (DFTD). Devils persist in regions of long‐term infection despite epidemiological model predictions of species’ extinction, suggesting possible adaptation to DFTD. Here, we test the extent to which spatial variation and genetic diversity are ...
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    Landscape genomics studies focus on identifying candidate genes under selection via spatial variation in abiotic environmental variables, but rarely by biotic factors (i.e., disease). The Tasmanian devil (Sarcophilus harrisii) is found only on the environmentally heterogeneous island of Tasmania and is threatened with extinction by a transmissible cancer, devil facial tumor disease (DFTD). Devils persist in regions of long‐term infection despite epidemiological model predictions of species’ extinction, suggesting possible adaptation to DFTD. Here, we test the extent to which spatial variation and genetic diversity are associated with the abiotic environment (i.e., climatic variables, elevation, vegetation cover) and/or DFTD. We employ genetic‐environment association analyses using 6886 SNPs from 3287 individuals sampled pre‐ and post‐disease arrival across the devil's geographic range. Pre‐disease, we find significant correlations of allele frequencies with environmental variables, including 365 unique loci linked to 71 genes, suggesting local adaptation to abiotic environment. The majority of candidate loci detected pre‐DFTD are not detected post‐DFTD arrival. Several post‐DFTD candidate loci are associated with disease prevalence and were in linkage disequilibrium with genes involved in tumor suppression and immune response. Loss of apparent signal of abiotic local adaptation post‐disease suggests swamping by strong selection resulting from the rapid onset of DFTD.
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    Journal Title
    Evolution
    Volume
    74
    Issue
    7
    DOI
    https://doi.org/10.1111/evo.14023
    Copyright Statement
    © 2020 Society for the Study of Evolution. This is the peer reviewed version of the following article: A, Disease swamps molecular signatures of genetic-environmental associations to abiotic factors in Tasmanian devil (Sarcophilus harrisii) populations, Evolution, 2020, 74 (7), pp. 1392-1408, which has been published in final form at https://doi.org/10.1111/evo.14023. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
    Subject
    Ecology
    Evolutionary biology
    Science & Technology
    Life Sciences & Biomedicine
    Genetics & Heredity
    Publication URI
    http://hdl.handle.net/10072/398160
    Collection
    • Journal articles

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