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dc.contributor.authorPark, Hyeongyu
dc.contributor.authorMasud, Mostafa Kamal
dc.contributor.authorNa, Jongbeom
dc.contributor.authorLim, Hyunsoo
dc.contributor.authorPhan, Hoang-Phuong
dc.contributor.authorKaneti, Yusuf Valentino
dc.contributor.authorAlothman, Asma A
dc.contributor.authorSalomon, Carlos
dc.contributor.authorNguyen, Nam-Trung
dc.contributor.authorHossain, Md Shahriar A
dc.contributor.authorYamauchi, Yusuke
dc.date.accessioned2020-10-08T00:42:25Z
dc.date.available2020-10-08T00:42:25Z
dc.date.issued2020
dc.identifier.issn2050-750X
dc.identifier.doi10.1039/d0tb02003f
dc.identifier.urihttp://hdl.handle.net/10072/398200
dc.description.abstractHerein, we report the preparation of mesoporous gold (Au)-silver (Ag) alloy films through the electrochemical micelle assembly process and their applications as microRNA (miRNA) sensors. Following electrochemical deposition and subsequent removal of the templates, the polymeric micelles can create uniformly sized mesoporous architectures with high surface areas. The resulting mesoporous Au-Ag alloy films show high current densities (electrocatalytic activities) towards the redox reaction between potassium ferrocyanide and potassium ferricyanide. Following magnetic isolation and purification, the target miRNA is adsorbed directly on the mesoporous Au-Ag film. Electrochemical detection is then enabled by differential pulse voltammetry (DPV) using the [Fe(CN)6]3-/4- redox system (the faradaic current for the miRNA-adsorbed Au-Ag film decreases compared to the bare film). The films demonstrate great advantages towards miRNA sensing platforms to enhance the detection limit down to attomolar levels of miR-21 (limit of detection (LOD) = 100 aM, s/n = 3). The developed enzymatic amplification-free miniaturized analytical sensor has promising potential for RNA-based diagnosis of diseases.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherRoyal Society of Chemistry (RSC)
dc.relation.ispartofjournalJournal of Materials Chemistry B
dc.subject.fieldofresearchMacromolecular and materials chemistry
dc.subject.fieldofresearchBiomedical engineering
dc.subject.fieldofresearchcode3403
dc.subject.fieldofresearchcode4003
dc.titleMesoporous gold-silver alloy films towards amplification-free ultra-sensitive microRNA detection
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationPark, H; Masud, MK; Na, J; Lim, H; Phan, H-P; Kaneti, YV; Alothman, AA; Salomon, C; Nguyen, N-T; Hossain, MSA; Yamauchi, Y, Mesoporous gold-silver alloy films towards amplification-free ultra-sensitive microRNA detection, Journal of Materials Chemistry B, 2020
dc.date.updated2020-10-08T00:07:30Z
gro.description.notepublicThis publication has been entered in Griffith Research Online as an advanced online version.
gro.hasfulltextNo Full Text
gro.griffith.authorNguyen, Nam-Trung


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