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  • A CREB1 gene polymorphism (rs2253206) is associated with prospective memory in a healthy cohort

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    Spriggens82713-Published.pdf (1.144Mb)
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    Version of Record (VoR)
    Author(s)
    Avgan, Nesli
    Sutherland, Heidi G
    Lea, Rodney A
    Spriggens, Lauren
    Haupt, Larisa M
    Shum, David
    Griffiths, Lyn R
    Griffith University Author(s)
    Shum, David
    Spriggens, Lauren
    Year published
    2017
    Metadata
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    Abstract
    Prospective memory (PM) is generally defined as remembering to perform intended actions in the future and is important for functioning in daily life. Cyclic adenosine monophosphate (cAMP) responsive element binding protein 1 (CREB1) plays an important role in cognitive functions. In this study, we hypothesized that genetic variation in the CREB1 gene is associated with PM. We genotyped a CREB1 promoter polymorphism rs2253206 and tested it for association with PM in 619 healthy subjects. PM performance was measured using the Prospective and Retrospective Memory Questionnaire (PRMQ), the Comprehensive Assessment of Prospective ...
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    Prospective memory (PM) is generally defined as remembering to perform intended actions in the future and is important for functioning in daily life. Cyclic adenosine monophosphate (cAMP) responsive element binding protein 1 (CREB1) plays an important role in cognitive functions. In this study, we hypothesized that genetic variation in the CREB1 gene is associated with PM. We genotyped a CREB1 promoter polymorphism rs2253206 and tested it for association with PM in 619 healthy subjects. PM performance was measured using the Prospective and Retrospective Memory Questionnaire (PRMQ), the Comprehensive Assessment of Prospective Memory (CAPM), and the Memory for Intentions Screening Test (MIST). Generalized linear model analysis was conducted for each PM test independently using different inheritance models to identify any associations (p < 0.05). After multiple testing adjustments, a significant association was found between the rs2253206 genotype and PM performance for CAPM instrumental activities of daily living measure (p = 0.016). These results suggest that the rs2253206 polymorphism in the CREB1 gene locus is associated with PM in healthy individuals and contributes to knowledge on the genetics of this particular type of memory.
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    Journal Title
    Frontiers in Behavioral Neuroscience
    Volume
    11
    DOI
    https://doi.org/10.3389/fnbeh.2017.00086
    Copyright Statement
    © 2017 Avgan, Sutherland, Lea, Spriggens, Haupt, Shum and Griffiths. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
    Subject
    Neurosciences
    Psychology
    Cognitive and computational psychology
    Cognition
    Science & Technology
    Life Sciences & Biomedicine
    Behavioral Sciences
    Neurosciences & Neurology
    Publication URI
    http://hdl.handle.net/10072/398283
    Collection
    • Journal articles

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