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  • Evaluation of the antibacterial activity and toxicity of Terminalia ferdinandia fruit extracts

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    Author(s)
    Cock, Ian
    Mohanty, Shimony
    Griffith University Author(s)
    Cock, Ian E.
    Mohanty, Shimony
    Year published
    2011
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    Abstract
    Introduction: Terminalia ferdinandiana is an endemic Australian native plant with a history of use as a food and as a medicinal agent by indigenous Australians. Yet the medicinal bioactivities of this plant are poorly studied. In the current study, solvent extracts from T. ferdinandiana fruit pulp were tested for antimicrobial activity and toxicity in vitro. Results: All extracts displayed antibacterial activity in the disc diffusion assay. The methanol extract proved to have the broadest specificity, inhibiting the growth of 13 of the 14 bacteria tested (92.9%). The deionised water extract inhibited the growth of 11 ...
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    Introduction: Terminalia ferdinandiana is an endemic Australian native plant with a history of use as a food and as a medicinal agent by indigenous Australians. Yet the medicinal bioactivities of this plant are poorly studied. In the current study, solvent extracts from T. ferdinandiana fruit pulp were tested for antimicrobial activity and toxicity in vitro. Results: All extracts displayed antibacterial activity in the disc diffusion assay. The methanol extract proved to have the broadest specificity, inhibiting the growth of 13 of the 14 bacteria tested (92.9%). The deionised water extract inhibited the growth of 11 of the 14 bacteria tested (78.6%). The ethyl acetate, chloroform and hexane extracts inhibited 21.4%, 28.6% and 14.3% respectively. T. ferdinandiana methanolic extracts were approximately equally effective against Grampositive (100%) and Gram-negative bacteria (90%). All other extracts were more effective at inhibiting the growth of Gram-positive bacteria. The water, ethyl acetate, chloroform and hexane extracts inhibited the growth of 100, 50, 50 and 50% Gram-positive bacteria respectively. In contrast, they inhibited the growth of 70, 10, 20 and 0% Gram-negative respectively. All T. ferdinandiana extracts were either non-toxic (ethyl acetate, chloroform, hexane) with no significant increase in mortality induction, or of low toxicity (LC50 >1000 姯ml) (methanol, deionised water) in the Artemia fransiscana bioassay. Conclusions: The low toxicity of the T. ferdinandiana extracts and their inhibitory bioactivity against bacteria validate Australian Aboriginal usage of T. ferdinandiana and indicates its medicinal potential as well as its potential as a source of natural ascorbic acid.
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    Journal Title
    Pharmacognosy Journal
    Volume
    3
    Issue
    20
    DOI
    https://doi.org/10.5530/pj.2011.20.14
    Copyright Statement
    © 2011 Phcog.net. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Biological Sciences not elsewhere classified
    Plant Biology
    Complementary and Alternative Medicine
    Pharmacology and Pharmaceutical Sciences
    Publication URI
    http://hdl.handle.net/10072/39832
    Collection
    • Journal articles

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