Show simple item record

dc.contributor.authorButton, Elise
dc.contributor.authorChan, Raymond Javan
dc.contributor.authorChambers, Shirley
dc.contributor.authorButler, Jason
dc.contributor.authorYates, Patsy
dc.date.accessioned2020-10-13T04:07:55Z
dc.date.available2020-10-13T04:07:55Z
dc.date.issued2017
dc.identifier.issn1471-2407
dc.identifier.doi10.1186/s12885-017-3207-7
dc.identifier.urihttp://hdl.handle.net/10072/398327
dc.description.abstractBackground: Accurate prognosticating is needed when patients are nearing the end of life to ensure appropriate treatment decisions, and facilitate palliative care provision and transitioning to terminal care. People with a hematological malignancy characteristically experience a fluctuating illness trajectory leading to difficulties with prognosticating. The aim of this review was to identify current knowledge regarding ‘bedside’ prognostic factors in the final 3 months of life for people with a hematological malignancy associated with increased risk of mortality. Methods: A systematic review of the literature was performed across: PubMed; CINAHL; PsycINFO; and Cochrane with set inclusion criteria: 1) prognostic cohort studies; 2) published 2004–2014; 3) sample ≥ 18 years; 4) >50% sample had a hematological malignancy; 5) reported ‘bedside’ prognostic factors; 6) median survival of <3 months; and 7) English language. Quality appraisal was performed using the Quality In Prognostic Studies (QUIPS) tool. Results are reported in line with PRISMA guidelines. Results: The search returned 4860 studies of which 28 met inclusion criteria. Twenty-four studies were rated moderate quality, three were high quality and one study was deemed to be of low quality. Most studies were set in the ICU (n = 24/28) and were retrospective (n = 25/28). Forty ‘bedside’ prognostic factors were identified as associated with increased risk of mortality encompassing the following broad categories: 1) demographics; 2) physiological complications or conditions; 3) disease characteristics; 4) laboratory blood values; and 5) interventions. Conclusions: The literature on prognosticating in the final months of life was predominantly focused on people who had experienced acute physiological deterioration and were being treated aggressively in the in-patient setting. A significant gap in the literature exists for people who are treated less aggressively or are on a palliative trajectory. Findings did not report on, or confirm the significance of, many of the key prognostic factors associated with increased risk of mortality at the end of life in the solid tumour population, demonstrating key differences in the two populations. Trial registration: This systematic review was not registered.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBMC
dc.relation.ispartofpagefrom213
dc.relation.ispartofissue1
dc.relation.ispartofjournalBMC Cancer
dc.relation.ispartofvolume17
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchHealth services and systems
dc.subject.fieldofresearchPublic health
dc.subject.fieldofresearchcode3211
dc.subject.fieldofresearchcode4203
dc.subject.fieldofresearchcode4206
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsOncology
dc.subject.keywordsHematological malignancies
dc.subject.keywordsPrognostic factors
dc.titleA systematic review of prognostic factors at the end of life for people with a hematological malignancy
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationButton, E; Chan, RJ; Chambers, S; Butler, J; Yates, P, A systematic review of prognostic factors at the end of life for people with a hematological malignancy, BMC Cancer, 2017, 17 (1), pp. 213
dcterms.dateAccepted2017-03-18
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-10-13T03:55:24Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
gro.hasfulltextFull Text
gro.griffith.authorChan, Ray


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record