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dc.contributor.authorCock, Ian
dc.contributor.authorMohanty, Shimony
dc.date.accessioned2017-05-03T11:29:06Z
dc.date.available2017-05-03T11:29:06Z
dc.date.issued2011
dc.date.modified2011-08-11T06:03:38Z
dc.identifier.issn09753575
dc.identifier.doi10.5530/pj.2011.20.14
dc.identifier.urihttp://hdl.handle.net/10072/39832
dc.description.abstractIntroduction: Terminalia ferdinandiana is an endemic Australian native plant with a history of use as a food and as a medicinal agent by indigenous Australians. Yet the medicinal bioactivities of this plant are poorly studied. In the current study, solvent extracts from T. ferdinandiana fruit pulp were tested for antimicrobial activity and toxicity in vitro. Results: All extracts displayed antibacterial activity in the disc diffusion assay. The methanol extract proved to have the broadest specificity, inhibiting the growth of 13 of the 14 bacteria tested (92.9%). The deionised water extract inhibited the growth of 11 of the 14 bacteria tested (78.6%). The ethyl acetate, chloroform and hexane extracts inhibited 21.4%, 28.6% and 14.3% respectively. T. ferdinandiana methanolic extracts were approximately equally effective against Grampositive (100%) and Gram-negative bacteria (90%). All other extracts were more effective at inhibiting the growth of Gram-positive bacteria. The water, ethyl acetate, chloroform and hexane extracts inhibited the growth of 100, 50, 50 and 50% Gram-positive bacteria respectively. In contrast, they inhibited the growth of 70, 10, 20 and 0% Gram-negative respectively. All T. ferdinandiana extracts were either non-toxic (ethyl acetate, chloroform, hexane) with no significant increase in mortality induction, or of low toxicity (LC50 >1000 姯ml) (methanol, deionised water) in the Artemia fransiscana bioassay. Conclusions: The low toxicity of the T. ferdinandiana extracts and their inhibitory bioactivity against bacteria validate Australian Aboriginal usage of T. ferdinandiana and indicates its medicinal potential as well as its potential as a source of natural ascorbic acid.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent2027274 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherPharmacognosy Network Worldwide
dc.publisher.placeIndia
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom72
dc.relation.ispartofpageto79
dc.relation.ispartofissue20
dc.relation.ispartofjournalPharmacognosy Journal
dc.relation.ispartofvolume3
dc.rights.retentionY
dc.subject.fieldofresearchPlant biology
dc.subject.fieldofresearchOther biological sciences not elsewhere classified
dc.subject.fieldofresearchTraditional, complementary and integrative medicine
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode3108
dc.subject.fieldofresearchcode319999
dc.subject.fieldofresearchcode4208
dc.subject.fieldofresearchcode3214
dc.titleEvaluation of the antibacterial activity and toxicity of Terminalia ferdinandia fruit extracts
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, School of Natural Sciences
gro.rights.copyright© 2011 Phcog.net. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2011
gro.hasfulltextFull Text
gro.griffith.authorCock, Ian E.


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