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dc.contributor.authorLi, B
dc.contributor.authorZhao, M
dc.contributor.authorFeng, L
dc.contributor.authorDou, C
dc.contributor.authorDing, S
dc.contributor.authorZhou, G
dc.contributor.authorLu, L
dc.contributor.authorZhang, H
dc.contributor.authorChen, F
dc.contributor.authorLi, X
dc.contributor.authorLi, G
dc.contributor.authorZhao, S
dc.contributor.authorJiang, C
dc.contributor.authorZhao, D
dc.contributor.authoret al.
dc.date.accessioned2020-10-13T23:51:59Z
dc.date.available2020-10-13T23:51:59Z
dc.date.issued2020
dc.identifier.issn2041-1723en_US
dc.identifier.doi10.1038/s41467-020-16924-zen_US
dc.identifier.urihttp://hdl.handle.net/10072/398349
dc.description.abstractReal-time monitoring of vessel dysfunction is of great significance in preclinical research. Optical bioimaging in the second near-infrared (NIR-II) window provides advantages including high resolution and fast feedback. However, the reported molecular dyes are hampered by limited blood circulation time (~ 5–60 min) and short absorption and emission wavelength, which impede the accurate long-term monitoring. Here, we report a NIR-II molecule (LZ-1105) with absorption and emission beyond 1000 nm. Thanks to the long blood circulation time (half-life of 3.2 h), the fluorophore is used for continuous real-time monitoring of dynamic vascular processes, including ischemic reperfusion in hindlimbs, thrombolysis in carotid artery and opening and recovery of the blood brain barrier (BBB). LZ-1105 provides an approach for researchers to assess vessel dysfunction due to the long excitation and emission wavelength and long-term blood circulation properties.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLCen_US
dc.relation.ispartofpagefrom3102en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalNature Communicationsen_US
dc.relation.ispartofvolume11en_US
dc.subject.fieldofresearchNanotechnologyen_US
dc.subject.fieldofresearchcode1007en_US
dc.titleOrganic NIR-II molecule with long blood half-life for in vivo dynamic vascular imagingen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationLi, B; Zhao, M; Feng, L; Dou, C; Ding, S; Zhou, G; Lu, L; Zhang, H; Chen, F; Li, X; Li, G; Zhao, S; Jiang, C; Zhao, D; et al., Organic NIR-II molecule with long blood half-life for in vivo dynamic vascular imaging, Nature Communications, 2020, 11 (1), pp. 3102en_US
dcterms.dateAccepted2020-05-29
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/en_US
dc.date.updated2020-10-13T23:45:01Z
dc.description.versionVersion of Record (VoR)en_US
gro.rights.copyright© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en_US
gro.hasfulltextFull Text
gro.griffith.authorZhao, Dongyuan


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