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dc.contributor.authorLau, CL
dc.contributor.authorStreeton, CL
dc.contributor.authorDavid, MC
dc.contributor.authorSly, PD
dc.contributor.authorMills, DJ
dc.date.accessioned2020-10-19T05:13:25Z
dc.date.available2020-10-19T05:13:25Z
dc.date.issued2016
dc.identifier.issn1195-1982en_US
dc.identifier.doi10.1093/jtm/tav023en_US
dc.identifier.urihttp://hdl.handle.net/10072/398467
dc.description.abstractBackground: Combined hepatitis A and typhoid vaccines have been widely used globally and proven to be safe, well tolerated and efficacious in adults. The combined hepatitis A and typhoid vaccine (Vivaxim) available in Australia is licenced for use from age 16 years but the monovalent components are approved for use from age 2 years. Advantages of a single injection have led to widespread ‘off-label’ use of Vivaxim in children. This study aimed to investigate the tolerability of Vivaxim in children aged 2–16 years. Methods: A prospective observational study was conducted at Travel Medicine Alliance clinics across Australia. Children who required vaccination for both hepatitis A and typhoid were offered the option of receiving Vivaxim. Parents were contacted 3 days post-vaccination and asked to respond to a questionnaire on adverse events following immunization (AEFIs). Reactions to Vivaxim were compared with reported reactions to the monovalent vaccines. Results: Our study included 425 children who received Vivaxim, including 189 (44.5%) who received other vaccines on the same day. No serious AEFIs were reported, and 26.8% did not experience any side effects. In children who did not receive other vaccines in the same arm as Vivaxim (n = 325), most common local reactions were sore arm (70.5%), redness (16.0%) and swelling (11.1%). Reports of local AEFIs in our subjects was significantly more common than those reported for the individual monovalent vaccines. In children who did not receive other vaccines on the same day (n = 236), the most common systemic reactions were tiredness/lethargy/malaise (5.9%), headache (4.2%), fever (3.4%) and sore muscles and joints (3.4%). Fever was more common in children aged <6 years. Less than 5% of children reported missing school, sport or other regular activities. Conclusions: Vivaxim was well tolerated in children aged 2–16 years. Parents should be advised about AEFIs to Vivaxim so that they can make informed decisions about vaccination options.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglish
dc.language.isoeng
dc.publisherOxford University Press (OUP)en_US
dc.relation.ispartofissue2en_US
dc.relation.ispartofjournalJournal of travel medicineen_US
dc.relation.ispartofvolume23en_US
dc.subject.fieldofresearchClinical Sciencesen_US
dc.subject.fieldofresearchPublic Health and Health Servicesen_US
dc.subject.fieldofresearchTourismen_US
dc.subject.fieldofresearchcode1103en_US
dc.subject.fieldofresearchcode1117en_US
dc.subject.fieldofresearchcode1506en_US
dc.subject.keywordsVaccineen_US
dc.subject.keywordschildrenen_US
dc.subject.keywordshepatitis Aen_US
dc.subject.keywordsimmunizationen_US
dc.subject.keywordstyphoiden_US
dc.titleThe tolerability of a combined hepatitis A and typhoid vaccine in children aged 2-16 years: an observational studyen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationLau, CL; Streeton, CL; David, MC; Sly, PD; Mills, DJ, The tolerability of a combined hepatitis A and typhoid vaccine in children aged 2-16 years: an observational study, Journal of travel medicine, 2016, 23 (2)en_US
dcterms.dateAccepted2015-11-19
dc.date.updated2020-10-19T03:10:52Z
gro.hasfulltextNo Full Text
gro.griffith.authorDavid, Michael


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