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dc.contributor.authorDavid, MC
dc.contributor.authorHa, SH
dc.contributor.authorPaynter, S
dc.contributor.authorLau, C
dc.date.accessioned2020-10-19T05:42:25Z
dc.date.available2020-10-19T05:42:25Z
dc.date.issued2015
dc.identifier.issn0264-410Xen_US
dc.identifier.doi10.1016/j.vaccine.2015.09.051en_US
dc.identifier.urihttp://hdl.handle.net/10072/398470
dc.description.abstractAn estimated 5–10% of adults do not seroconvert after a three-dose primary course of hepatitis B vaccines, and are considered non-responders. Many approaches have been used to induce immunity in healthy adult non-responders, but few studies have compared their relative effectiveness. We conducted a systematic review and meta-analysis of seroconversion rates after additional doses of four approaches: 20 mcg or 40 mcg intramuscular (IM), and 5 mcg or 20 mcg intradermal (ID). The search identified 13 articles encompassing 16 studies (N = 1067) that met the eligibility criteria. Seroconversion rates after additional doses of each approach were pooled and estimated. After one additional dose, the four approaches produced very similar seroconversion rates and we did not find any evidence to support the use of 40 mcg IM in healthy adults.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom6564en_US
dc.relation.ispartofpageto6569en_US
dc.relation.ispartofissue48en_US
dc.relation.ispartofjournalVaccineen_US
dc.relation.ispartofvolume33en_US
dc.subject.fieldofresearchImmunologyen_US
dc.subject.fieldofresearchBiological Sciencesen_US
dc.subject.fieldofresearchAgricultural and Veterinary Sciencesen_US
dc.subject.fieldofresearchMedical and Health Sciencesen_US
dc.subject.fieldofresearchcode1107en_US
dc.subject.fieldofresearchcode06en_US
dc.subject.fieldofresearchcode07en_US
dc.subject.fieldofresearchcode11en_US
dc.subject.keywordsHepatitis Ben_US
dc.subject.keywordsImmunisationen_US
dc.subject.keywordsMeta-analysisen_US
dc.subject.keywordsSeroconversion rateen_US
dc.subject.keywordsVaccinationen_US
dc.titleA systematic review and meta-analysis of management options for adults who respond poorly to hepatitis B vaccinationen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationDavid, MC; Ha, SH; Paynter, S; Lau, C, A systematic review and meta-analysis of management options for adults who respond poorly to hepatitis B vaccination, Vaccine, 2015, 33 (48), pp. 6564-6569en_US
dcterms.dateAccepted2015-09-17
dc.date.updated2020-10-19T04:01:25Z
gro.hasfulltextNo Full Text
gro.griffith.authorDavid, Michael


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