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  • Psammaplysin H, a new antimalarial bromotyrosine alkaloid from a marine sponge of the genus Pseudoceratina

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    Author(s)
    Xu, Min
    Andrews, Kathy T
    Birrell, Geoff W
    Tran, Truc Linh
    Camp, David
    Davis, Rohan A
    Quinn, Ronald J
    Griffith University Author(s)
    Quinn, Ronald J.
    Camp, David B.
    Andrews, Katherine T.
    Davis, Rohan A.
    Tran, Trong D.
    Xu, Min
    Year published
    2011
    Metadata
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    Abstract
    Mass-directed isolation of the CH(2)Cl(2)/CH(3)OH extract from a marine sponge of the genus Pseudoceratina resulted in the purification of a new antimalarial bromotyrosine alkaloid, psammaplysin H (1), along with the previously isolated analogs psammaplysins G (2) and F (3). The structure of 1 was elucidated following 1D and 2D NMR, and MS data analysis. All compounds were tested in vitro against the 3D7 line of Plasmodium falciparum and mammalian cell lines (HEK293 and HepG2), with 1 having the most potent (IC(50) 0.41muM) and selective (>97-fold) antimalarial activity.Mass-directed isolation of the CH(2)Cl(2)/CH(3)OH extract from a marine sponge of the genus Pseudoceratina resulted in the purification of a new antimalarial bromotyrosine alkaloid, psammaplysin H (1), along with the previously isolated analogs psammaplysins G (2) and F (3). The structure of 1 was elucidated following 1D and 2D NMR, and MS data analysis. All compounds were tested in vitro against the 3D7 line of Plasmodium falciparum and mammalian cell lines (HEK293 and HepG2), with 1 having the most potent (IC(50) 0.41muM) and selective (>97-fold) antimalarial activity.
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    Journal Title
    Bioorganic & Medicinal Chemistry Letters
    Volume
    21
    Issue
    2
    DOI
    https://doi.org/10.1016/j.bmcl.2010.11.081
    Copyright Statement
    © 2010 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Medicinal and biomolecular chemistry
    Medicinal and biomolecular chemistry not elsewhere classified
    Organic chemistry
    Pharmacology and pharmaceutical sciences
    Publication URI
    http://hdl.handle.net/10072/39866
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    • Journal articles

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