Show simple item record

dc.contributor.authorCampling, James
dc.contributor.authorJones, Dylan
dc.contributor.authorChalmers, James
dc.contributor.authorJiang, Qin
dc.contributor.authorVyse, Andrew
dc.contributor.authorMadhava, Harish
dc.contributor.authorEllsbury, Gillian
dc.contributor.authorRabe, Adrian
dc.contributor.authorSlack, Mary
dc.date.accessioned2020-10-26T03:39:10Z
dc.date.available2020-10-26T03:39:10Z
dc.date.issued2020
dc.identifier.issn2052-4439
dc.identifier.doi10.1136/bmjresp-2020-000703
dc.identifier.urihttp://hdl.handle.net/10072/398683
dc.description.abstractBACKGROUND: Hospitalised pneumonia may have long-term clinical and financial impact in adult patients with underlying comorbidities. METHODS: We conducted a retrospective cohort study using the Hospital Episode Statistics (HES) database to determine the clinical and financial burden over 3 years of hospitalised community-acquired pneumonia (CAP) to England's National Health Service (NHS). Subjects were adults with six underlying comorbidities (chronic heart disease (CHD); chronic kidney disease (CKD); chronic liver disease (CLD); chronic respiratory disease (CRD); diabetes mellitus (DM) and post bone marrow transplant (post-BMT)) with an inpatient admission in 2012/2013. Patients with CAP in 2013/2014 were followed for 3 years and compared with similarly aged, propensity score-matched adults with the same comorbidity without CAP. FINDINGS: The RR of hospital admissions increased after CAP, ranging from 1.08 (95% CI 1.04 to 1.12) for CKD to 1.38 (95% CI 1.35 to 1.40) for CRD. This increase was maintained for at least 2 years. Mean difference in hospital healthcare costs (£) was higher for CAP patients in 2013/2014; ranging from £1115 for DM to £8444 for BMT, and remained higher for 4/6 groups for 2 more years, ranging from £1907 (95% CI £1573 to £2240) for DM to £11 167 (95% CI £10 847 to £11 486) for CRD.) The OR for mortality was significantly higher for at least 3 years after CAP, ranging from 4.76 (95% CI 4.12 to 5.51, p<0.0001) for CLD to 7.50 (95%CI 4.71 to 11.92, p<0.0001) for BMT. INTERPRETATION: For patients with selected underlying comorbidities, healthcare utilisation, costs and mortality increase for at least 3 years after being hospitalised CAP.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBMJ
dc.relation.ispartofpagefrome000703
dc.relation.ispartofissue1
dc.relation.ispartofjournalBMJ Open Respiratory Research
dc.relation.ispartofvolume7
dc.subject.fieldofresearchHealth services and systems
dc.subject.fieldofresearchPublic health
dc.subject.fieldofresearchcode4203
dc.subject.fieldofresearchcode4206
dc.subject.keywordspneumonia
dc.subject.keywordsrespiratory infection
dc.titleClinical and financial burden of hospitalised community-acquired pneumonia in patients with selected underlying comorbidities in England
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationCampling, J; Jones, D; Chalmers, J; Jiang, Q; Vyse, A; Madhava, H; Ellsbury, G; Rabe, A; Slack, M, Clinical and financial burden of hospitalised community-acquired pneumonia in patients with selected underlying comorbidities in England, BMJ Open Respiratory Research, 2020, 7 (1), pp. e000703
dcterms.dateAccepted2020-08-21
dcterms.licensehttps://creativecommons.org/licenses/by-nc/4.0/
dc.date.updated2020-10-25T23:54:39Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© Author(s) (or their employer(s)) 2020. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
gro.hasfulltextFull Text
gro.griffith.authorSlack, Mary P.


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record