dc.contributor.author | Campling, James | |
dc.contributor.author | Jones, Dylan | |
dc.contributor.author | Chalmers, James | |
dc.contributor.author | Jiang, Qin | |
dc.contributor.author | Vyse, Andrew | |
dc.contributor.author | Madhava, Harish | |
dc.contributor.author | Ellsbury, Gillian | |
dc.contributor.author | Rabe, Adrian | |
dc.contributor.author | Slack, Mary | |
dc.date.accessioned | 2020-10-26T03:39:10Z | |
dc.date.available | 2020-10-26T03:39:10Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 2052-4439 | |
dc.identifier.doi | 10.1136/bmjresp-2020-000703 | |
dc.identifier.uri | http://hdl.handle.net/10072/398683 | |
dc.description.abstract | BACKGROUND: Hospitalised pneumonia may have long-term clinical and financial impact in adult patients with underlying comorbidities. METHODS: We conducted a retrospective cohort study using the Hospital Episode Statistics (HES) database to determine the clinical and financial burden over 3 years of hospitalised community-acquired pneumonia (CAP) to England's National Health Service (NHS). Subjects were adults with six underlying comorbidities (chronic heart disease (CHD); chronic kidney disease (CKD); chronic liver disease (CLD); chronic respiratory disease (CRD); diabetes mellitus (DM) and post bone marrow transplant (post-BMT)) with an inpatient admission in 2012/2013. Patients with CAP in 2013/2014 were followed for 3 years and compared with similarly aged, propensity score-matched adults with the same comorbidity without CAP. FINDINGS: The RR of hospital admissions increased after CAP, ranging from 1.08 (95% CI 1.04 to 1.12) for CKD to 1.38 (95% CI 1.35 to 1.40) for CRD. This increase was maintained for at least 2 years. Mean difference in hospital healthcare costs (£) was higher for CAP patients in 2013/2014; ranging from £1115 for DM to £8444 for BMT, and remained higher for 4/6 groups for 2 more years, ranging from £1907 (95% CI £1573 to £2240) for DM to £11 167 (95% CI £10 847 to £11 486) for CRD.) The OR for mortality was significantly higher for at least 3 years after CAP, ranging from 4.76 (95% CI 4.12 to 5.51, p<0.0001) for CLD to 7.50 (95%CI 4.71 to 11.92, p<0.0001) for BMT. INTERPRETATION: For patients with selected underlying comorbidities, healthcare utilisation, costs and mortality increase for at least 3 years after being hospitalised CAP. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | BMJ | |
dc.relation.ispartofpagefrom | e000703 | |
dc.relation.ispartofissue | 1 | |
dc.relation.ispartofjournal | BMJ Open Respiratory Research | |
dc.relation.ispartofvolume | 7 | |
dc.subject.fieldofresearch | Health services and systems | |
dc.subject.fieldofresearch | Public health | |
dc.subject.fieldofresearchcode | 4203 | |
dc.subject.fieldofresearchcode | 4206 | |
dc.subject.keywords | pneumonia | |
dc.subject.keywords | respiratory infection | |
dc.title | Clinical and financial burden of hospitalised community-acquired pneumonia in patients with selected underlying comorbidities in England | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | Campling, J; Jones, D; Chalmers, J; Jiang, Q; Vyse, A; Madhava, H; Ellsbury, G; Rabe, A; Slack, M, Clinical and financial burden of hospitalised community-acquired pneumonia in patients with selected underlying comorbidities in England, BMJ Open Respiratory Research, 2020, 7 (1), pp. e000703 | |
dcterms.dateAccepted | 2020-08-21 | |
dcterms.license | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.date.updated | 2020-10-25T23:54:39Z | |
dc.description.version | Version of Record (VoR) | |
gro.rights.copyright | © Author(s) (or their employer(s)) 2020. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Slack, Mary P. | |