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dc.contributor.authorWang, Shuang
dc.contributor.authorSarwat, Mariah
dc.contributor.authorWang, Peng
dc.contributor.authorSurrao, Denver C
dc.contributor.authorHarkin, Damien G
dc.contributor.authorSt John, James A
dc.contributor.authorBolle, Eleonore CL
dc.contributor.authorForget, Aurelien
dc.contributor.authorDalton, Paul D
dc.contributor.authorDargaville, Tim R
dc.date.accessioned2020-10-27T04:39:36Z
dc.date.available2020-10-27T04:39:36Z
dc.date.issued2020
dc.identifier.issn1022-1336
dc.identifier.doi10.1002/marc.202000295
dc.identifier.urihttp://hdl.handle.net/10072/398765
dc.description.abstractA method is reported for making hollow channels within hydrogels decorated with cell-adhesion peptides exclusively at the channel surface. Sacrificial fibers of different diameters are used to introduce channels within poly(ethylene glycol) hydrogels crosslinked with maleimide-thiol chemistry, which are backfilled with a cysteine-containing peptide solution which is conjugated to the lumen with good spatial efficiency. This allows for peptide patterning in only the areas of the hydrogel where they are needed when used as cell-guides, reducing the amount of required peptide 20-fold when compared to bulk functionalization. The power of this approach is highlighted by successfully using these patterned hydrogels without active perfusion to guide fibroblasts and olfactory ensheathing cells-the latter having unique potential in neural repair therapies.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofpagefrom2000295
dc.relation.ispartofissue15
dc.relation.ispartofjournalMacromolecular Rapid Communications
dc.relation.ispartofvolume41
dc.subject.fieldofresearchChemical Sciences
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchcode03
dc.subject.fieldofresearchcode09
dc.subject.keywordsScience & Technology
dc.subject.keywordsPhysical Sciences
dc.subject.keywordsPolymer Science
dc.subject.keywords3D printing
dc.subject.keywordscell guidance
dc.titleHydrogels with Cell Adhesion Peptide-Decorated Channel Walls for Cell Guidance
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationWang, S; Sarwat, M; Wang, P; Surrao, DC; Harkin, DG; St John, JA; Bolle, ECL; Forget, A; Dalton, PD; Dargaville, TR, Hydrogels with Cell Adhesion Peptide-Decorated Channel Walls for Cell Guidance, Macromolecular Rapid Communications, 2020, 41 (15), pp. 2000295
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-10-27T04:36:43Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorSt John, James A.
gro.griffith.authorSurrao, Denver


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