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dc.contributor.authorGarces, Gil Triginer
dc.contributor.authorChrzanowski, Helen M
dc.contributor.authorDaryanoosh, Shakib
dc.contributor.authorThiel, Valerian
dc.contributor.authorMarchant, Anna L
dc.contributor.authorPatel, Raj B
dc.contributor.authorHumphreys, Peter C
dc.contributor.authorDatta, Animesh
dc.contributor.authorWalmsley, Ian A
dc.date.accessioned2020-10-28T04:24:56Z
dc.date.available2020-10-28T04:24:56Z
dc.date.issued2020
dc.identifier.issn0003-6951
dc.identifier.doi10.1063/5.0009681
dc.identifier.urihttp://hdl.handle.net/10072/398809
dc.description.abstractNonlinear optical microscopy techniques have emerged as a set of successful tools for biological imaging. Stimulated emission microscopy belongs to a small subset of pump-probe techniques, which can image non-fluorescent samples without requiring fluorescent labeling. However, its sensitivity has been shown to be ultimately limited by the quantum fluctuations in the probe beam. We propose and experimentally implement sub-shot-noise limited stimulated emission microscopy by preparing the probe pulse in an intensity-squeezed state. This technique paves the way for imaging delicate biological samples that have no detectable fluorescence with sensitivity beyond standard quantum fluctuations.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Institute of Physics (AIP Publishing)
dc.relation.ispartofpagefrom024002
dc.relation.ispartofissue2
dc.relation.ispartofjournalApplied Physics Letters
dc.relation.ispartofvolume117
dc.subject.fieldofresearchPhysical Sciences
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchTechnology
dc.subject.fieldofresearchcode02
dc.subject.fieldofresearchcode09
dc.subject.fieldofresearchcode10
dc.subject.keywordsScience & Technology
dc.subject.keywordsPhysics, Applied
dc.subject.keywordsPhysics
dc.subject.keywordsFLUORESCENCE
dc.titleQuantum-enhanced stimulated emission detection for label-free microscopy
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationGarces, GT; Chrzanowski, HM; Daryanoosh, S; Thiel, V; Marchant, AL; Patel, RB; Humphreys, PC; Datta, A; Walmsley, IA, Quantum-enhanced stimulated emission detection for label-free microscopy, Applied Physics Letters, 2020, 117 (2), pp. 024002
dc.date.updated2020-10-28T04:20:02Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2020 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Applied Physics Letters, 117, 024002 (2020) and may be found at https://doi.org/10.1063/5.0009681
gro.hasfulltextFull Text
gro.griffith.authorPatel, Raj B.


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