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dc.contributor.authorMeneses, AL
dc.contributor.authorNam, MCY
dc.contributor.authorBailey, TG
dc.contributor.authorAnstey, C
dc.contributor.authorGolledge, J
dc.contributor.authorKeske, MA
dc.contributor.authorGreaves, K
dc.contributor.authorAskew, CD
dc.date.accessioned2020-10-30T00:09:39Z
dc.date.available2020-10-30T00:09:39Z
dc.date.issued2020
dc.identifier.issn2051-817X
dc.identifier.doi10.14814/phy2.14580
dc.identifier.urihttp://hdl.handle.net/10072/398842
dc.description.abstractImpairments in skeletal muscle microvascular function are frequently reported in patients with various cardiometabolic conditions for which older age is a risk factor. Whether aging per se predisposes the skeletal muscle to microvascular dysfunction is unclear. We used contrast‐enhanced ultrasound (CEU) to compare skeletal muscle microvascular perfusion responses to cuff occlusion and leg exercise between healthy young (n = 12, 26 ± 3 years) and older (n = 12, 68 ± 7 years) adults. Test–retest reliability of CEU perfusion parameters was also assessed. Microvascular perfusion (microvascular volume × flow velocity) of the medial gastrocnemius muscle was measured before and immediately after: (a) 5‐min of thigh‐cuff occlusion, and (b) 5‐min of submaximal intermittent isometric plantar‐flexion exercise (400 N) using CEU. Whole‐leg blood flow was measured using strain‐gauge plethysmography. Repeated measures were obtained with a 15‐min interval, and averaged responses were used for comparisons between age groups. There were no differences in post‐occlusion whole‐leg blood flow and muscle microvascular perfusion between young and older participants (p > .05). Similarly, total whole‐leg blood flow during exercise and post‐exercise peak muscle microvascular perfusion did not differ between groups (p > .05). The overall level of agreement between the test–retest measures of calf muscle perfusion was excellent for measurements taken at rest (intraclass correlation coefficient [ICC] 0.85), and in response to cuff occlusion (ICC 0.89) and exercise (ICC 0.95). Our findings suggest that healthy aging does not affect muscle perfusion responses to cuff‐occlusion and submaximal leg exercise. CEU muscle perfusion parameters measured in response to these provocation tests are highly reproducible in both young and older adults.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofpagefrome14580
dc.relation.ispartofissue19
dc.relation.ispartofjournalPhysiological Reports
dc.relation.ispartofvolume8
dc.subject.fieldofresearchZoology
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchMedical physiology
dc.subject.fieldofresearchcode3109
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3208
dc.subject.keywordsaging
dc.subject.keywordsblood flow
dc.subject.keywordsexercise
dc.subject.keywordsmuscle perfusion
dc.subject.keywordsreactive hyperemia
dc.titleSkeletal muscle microvascular perfusion responses to cuff occlusion and submaximal exercise assessed by contrast-enhanced ultrasound: The effect of age
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMeneses, AL; Nam, MCY; Bailey, TG; Anstey, C; Golledge, J; Keske, MA; Greaves, K; Askew, CD, Skeletal muscle microvascular perfusion responses to cuff occlusion and submaximal exercise assessed by contrast-enhanced ultrasound: The effect of age, Physiological Reports, 2020, 8 (19), pp. e14580
dcterms.dateAccepted2020-08-28
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-10-29T21:57:21Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2020 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorAnstey, Chris


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