Show simple item record

dc.contributor.authorEl-Deeb, Ibrahim Mustafaen_US
dc.contributor.authorHan, Dong Keunen_US
dc.contributor.authorKim, In Taeen_US
dc.contributor.authorLee, Soen_US
dc.date.accessioned2017-04-04T22:43:15Z
dc.date.available2017-04-04T22:43:15Z
dc.date.issued2010en_US
dc.date.modified2011-08-12T06:18:43Z
dc.identifier.issn02532964en_US
dc.identifier.doi10.5012/bkcs.2010.31.7.1848en_AU
dc.identifier.urihttp://hdl.handle.net/10072/39884
dc.description.abstractPhenylaminopyrimidines represent a large group of new selective anticancer agents, the majority of which exert their action through the inhibition of specific kinases. In this study, a new series of N-substituted-2-aminopyrimidines has been designed and synthesized. A selected group of the synthesized derivatives was screened at a single dose concentration of 10 占over a panel of 60 cancer cell-lines. Compound 12e has showed great inhibitory and strong lethal effect over almost all of the 60 cell-lines and accordingly was further tested in a 5-dose testing mode to determine its IC50 values, where it showed great efficacies with intermediate potencies over the tested cell-lines. The compound was also tested over a panel of 52 kinases to explore its kinase inhibitory profile, and was found to be a selective but moderate inhibitor over FLT3 kinase.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherKorean Chemical Societyen_US
dc.publisher.placeSouth Koreaen_US
dc.relation.ispartofstudentpublicationYen_AU
dc.relation.ispartofpagefrom1848en_US
dc.relation.ispartofpageto1858en_US
dc.relation.ispartofissue7en_AU
dc.relation.ispartofjournalBulletin of the Korean Chemical Societyen_US
dc.relation.ispartofvolume31en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchBiologically Active Moleculesen_US
dc.subject.fieldofresearchcode030401en_US
dc.titleNew Phenylaminopyrimidine (PAP) Anticancer Lead Compound with High Efficacy: Design, Synthesis, and in vitro Screeningen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2010
gro.hasfulltextNo Full Text


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record