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  • Synthesis and in vivo studies of carbohydrate-based vaccines against group A Streptococcus

    Author(s)
    Simerska, Pavla
    Abdel-Aal, Abu-Baker M.
    Fujita, Yoshio
    Batzloff, Michael R.
    Good, Michael Francis
    Toth, Istvan
    Griffith University Author(s)
    Good, Michael F.
    Year published
    2008
    Metadata
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    Abstract
    Carbohydrates, as carriers, providing numerous attachment points for the conjugation of peptide antigens and their optimal orientation for the recognition by cells of the immune system, reducing degradation of the attached peptide antigens and many other advantages make carbohydrate-based vaccine highly promising approach. Multiple copies of a single group A streptococcal (GAS) M protein derived specific peptide antigens (J8 or J14) were coupled onto carbohydrate cores (D-glucose and D-galactose) linked to lipophilic amino acids to produce a self-adjuvanting liposaccharide vaccine against GAS strains. In vivo experiments ...
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    Carbohydrates, as carriers, providing numerous attachment points for the conjugation of peptide antigens and their optimal orientation for the recognition by cells of the immune system, reducing degradation of the attached peptide antigens and many other advantages make carbohydrate-based vaccine highly promising approach. Multiple copies of a single group A streptococcal (GAS) M protein derived specific peptide antigens (J8 or J14) were coupled onto carbohydrate cores (D-glucose and D-galactose) linked to lipophilic amino acids to produce a self-adjuvanting liposaccharide vaccine against GAS strains. In vivo experiments showed high serum IgG antibody titers against each of the incorporated peptide epitopes, J8 or J14.
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    Journal Title
    Peptide Science
    Volume
    90
    Issue
    5
    DOI
    https://doi.org/10.1002/bip.20992
    Subject
    Chemical Sciences not elsewhere classified
    Chemical Sciences
    Biological Sciences
    Publication URI
    http://hdl.handle.net/10072/39892.1
    Collection
    • Journal articles

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