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dc.contributor.authorCooper, Oren
dc.contributor.authorPhan, Hoang-Phuong
dc.contributor.authorWang, Bei
dc.contributor.authorLowe, Sean
dc.contributor.authorDay, Christopher J
dc.contributor.authorNguyen, Nam-Trung
dc.contributor.authorTiralongo, Joe
dc.date.accessioned2020-11-04T22:19:30Z
dc.date.available2020-11-04T22:19:30Z
dc.date.issued2020
dc.identifier.issn0743-7463
dc.identifier.doi10.1021/acs.langmuir.0c01306
dc.identifier.urihttp://hdl.handle.net/10072/398929
dc.description.abstractCurrently available bioplatforms such as microarrays and surface plasmon resonators are unable to combine high-throughput multiplexing with label-free detection. As such, emerging microelectromechanical systems (MEMS) and microplasmonics platforms offer the potential for high-resolution, high-throughput label-free sensing of biological and chemical analytes. Therefore, the search for materials capable of combining multiplexing and label-free quantitation is of great significance. Recently, interest in silicon carbide (SiC) as a suitable material in numerous biomedical applications has increased due to its well-explored chemical inertness, mechanical strength, bio- and hemocompatibility, and the presence of carbon that enables the transfer-free growth of graphene. SiC is also multifunctional as both a wide-band-gap semiconductor and an efficient low-loss plasmonics material and thus is ideal for augmenting current biotransducers in biosensors. Additionally, the cubic variant, 3C-SiC, is an extremely promising material for MEMS, being a suitable platform for the easy micromachining of microcantilevers, and as such capable of realizing the potential of real time miniaturized multiplexed assays. The generation of an appropriately functionalized and versatile organic monolayer suitable for the immobilization of biomolecules is therefore critical to explore label-free, multiplexed quantitation of biological interactions on SiC. Herein, we address the use of various silane self-assembled monolayers (SAMs) for the covalent functionalization of monocrystalline 3C-SiC films as a novel platform for the generation of functionalized microarray surfaces using high-throughput glycan arrays as the model system. We also demonstrate the ability to robotically print high throughput arrays on free-standing SiC microstructures. The implementation of a SiC-based label-free glycan array will provide a proof of principle that could be extended to the immobilization of other biomolecules in a similar SiC-based array format, thus making potentially significant advances to the way biological interactions are studied.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society (ACS)
dc.relation.ispartofjournalLangmuir
dc.subject.fieldofresearchChemical Sciences
dc.subject.fieldofresearchcode03
dc.titleFunctional Microarray Platform with Self-Assembled Monolayers on 3C-Silicon Carbide
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationCooper, O; Phan, H-P; Wang, B; Lowe, S; Day, CJ; Nguyen, N-T; Tiralongo, J, Functional Microarray Platform with Self-Assembled Monolayers on 3C-Silicon Carbide, Langmuir
dc.date.updated2020-11-03T04:14:51Z
dc.description.versionAccepted Manuscript (AM)
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.rights.copyrightThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Langmuir, copyright 2020 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see 10.1021/acs.langmuir.0c01306
gro.hasfulltextFull Text
gro.griffith.authorTiralongo, Joe
gro.griffith.authorCooper, Oren
gro.griffith.authorPhan, Hoang Phuong
gro.griffith.authorWang, Bei
gro.griffith.authorLowe, Sean
gro.griffith.authorDay, Christopher J.
gro.griffith.authorNguyen, Nam-Trung


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