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dc.contributor.authorLiu, Yuruen_US
dc.contributor.authorL. Haas, Debraen_US
dc.contributor.authorPoore, Spenceren_US
dc.contributor.authorIsakovic, Sanjinen_US
dc.contributor.authorGahan, Michelleen_US
dc.contributor.authorMahalingam, Sureshen_US
dc.contributor.authorF. Fu, Zhenen_US
dc.contributor.authorA. Tripp, Ralphen_US
dc.date.accessioned2017-04-24T12:19:27Z
dc.date.available2017-04-24T12:19:27Z
dc.date.issued2009en_US
dc.date.modified2011-08-12T06:19:03Z
dc.identifier.issn0022538Xen_US
dc.identifier.doi10.1128/JVI.00379-09en_AU
dc.identifier.urihttp://hdl.handle.net/10072/39894
dc.description.abstractHuman metapneumovirus (HMPV) has been identified as a worldwide agent of serious upper and lower respiratory tract infections in infants and young children. HMPV is second only to respiratory syncytial virus (RSV) as a leading cause of bronchiolitis, and, like RSV, consists of two major genotypes that cocirculate and vary among communities year to year. Children who have experienced acute HMPV infection may develop sequelae of wheezing and asthma; however, the features contributing to this pathology remain unknown. A possible mechanism for postbronchiolitis disease is that HMPV might persist in the lung providing a stimulus that could contribute to wheezing and asthma. Using immunohistochemistry to identify HMPV-infected cells in the lungs of mice, we show that HMPV mediates biphasic replication in respiratory epithelial cells then infection migrates to neuronal processes that innervate the lungs where the virus persists with no detectable infection in epithelial cells. After glucocorticoid treatment, the virus is reactivated from neural fibers and reinfects epithelial cells. The findings show that HMPV persists in neural fibers and suggest a mechanism for disease chronicity that has important implications for HMPV disease intervention strategies.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherAmerican Society for Microbiologyen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom6837en_US
dc.relation.ispartofpageto6848en_US
dc.relation.ispartofissue13en_US
dc.relation.ispartofjournalJournal of Virologyen_US
dc.relation.ispartofvolume83en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchMicrobiology not elsewhere classifieden_US
dc.subject.fieldofresearchcode060599en_US
dc.titleHuman Metapneumovirus Establishes Persistent Infection in the Lungs of Mice and Is Reactivated by Glucocorticoid Treatmenten_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2009
gro.hasfulltextNo Full Text


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