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dc.contributor.authorLiu, Yuru
dc.contributor.authorL. Haas, Debra
dc.contributor.authorPoore, Spencer
dc.contributor.authorIsakovic, Sanjin
dc.contributor.authorGahan, Michelle
dc.contributor.authorMahalingam, Suresh
dc.contributor.authorF. Fu, Zhen
dc.contributor.authorA. Tripp, Ralph
dc.date.accessioned2017-09-04T03:26:38Z
dc.date.available2017-09-04T03:26:38Z
dc.date.issued2009
dc.date.modified2011-08-12T06:19:03Z
dc.identifier.issn0022538Xen_US
dc.identifier.doi10.1128/JVI.00379-09en_US
dc.identifier.urihttp://hdl.handle.net/10072/39894
dc.description.abstractHuman metapneumovirus (HMPV) has been identified as a worldwide agent of serious upper and lower respiratory tract infections in infants and young children. HMPV is second only to respiratory syncytial virus (RSV) as a leading cause of bronchiolitis, and, like RSV, consists of two major genotypes that cocirculate and vary among communities year to year. Children who have experienced acute HMPV infection may develop sequelae of wheezing and asthma; however, the features contributing to this pathology remain unknown. A possible mechanism for postbronchiolitis disease is that HMPV might persist in the lung providing a stimulus that could contribute to wheezing and asthma. Using immunohistochemistry to identify HMPV-infected cells in the lungs of mice, we show that HMPV mediates biphasic replication in respiratory epithelial cells then infection migrates to neuronal processes that innervate the lungs where the virus persists with no detectable infection in epithelial cells. After glucocorticoid treatment, the virus is reactivated from neural fibers and reinfects epithelial cells. The findings show that HMPV persists in neural fibers and suggest a mechanism for disease chronicity that has important implications for HMPV disease intervention strategies.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherAmerican Society for Microbiologyen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom6837en_US
dc.relation.ispartofpageto6848en_US
dc.relation.ispartofissue13en_US
dc.relation.ispartofjournalJournal of Virologyen_US
dc.relation.ispartofvolume83en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchMicrobiology not elsewhere classifieden_US
dc.subject.fieldofresearchcode060599en_US
dc.titleHuman Metapneumovirus Establishes Persistent Infection in the Lungs of Mice and Is Reactivated by Glucocorticoid Treatmenten_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
dc.description.versionPublisheden_US
gro.rights.copyrightCopyright 2009 American Society for Microbiology. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.en_US
gro.date.issued2009
gro.hasfulltextFull Text


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