dc.contributor.author | Ramsay, N | |
dc.contributor.author | Macleod, AD | |
dc.contributor.author | Alves, G | |
dc.contributor.author | Camacho, M | |
dc.contributor.author | Forsgren, L | |
dc.contributor.author | Lawson, RA | |
dc.contributor.author | Maple-Grødem, J | |
dc.contributor.author | Tysnes, OB | |
dc.contributor.author | Williams-Gray, CH | |
dc.contributor.author | Yarnall, AJ | |
dc.contributor.author | Counsell, CE | |
dc.contributor.author | Rachael A Lawson | |
dc.contributor.author | Guido Alves, S | |
dc.contributor.author | Khoo, TK | |
dc.contributor.author | et al. | |
dc.date.accessioned | 2020-11-04T03:53:07Z | |
dc.date.available | 2020-11-04T03:53:07Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 1353-8020 | |
dc.identifier.doi | 10.1016/j.parkreldis.2020.05.034 | |
dc.identifier.uri | http://hdl.handle.net/10072/398957 | |
dc.description.abstract | Introduction: Functional dependency in basic activities of daily living (ADLs) is a key outcome in Parkinson's disease (PD). We aimed to define dependency in PD, using the original and MDS versions of the Unified Parkinson's Disease Rating Scale (UPDRS). Methods: We developed two algorithms to define dependency from items of UPDRS Part 2 and MDS-UPDRS Part 2 relating to basic ADLs (feeding, dressing, hygiene and walking, and getting out of a chair). We validated both algorithms using data from 1110 patients from six community-based PD incidence cohorts, testing concurrent validity, convergent validity, and predictive validity. Results: Our optimal algorithm showed high specificity and moderate to high sensitivity versus Schwab & England <80% (specificity 95% [95% confidence interval (CI) 93–97] and sensitivity 65% [95% CI 55–73] at baseline; 88% [95% CI 85–91] and 85% [95% CI 79–97] respectively at five-years follow-up). Convergent validity was demonstrated by strong associations between dependency defined by the algorithm and cognition (MMSE), quality of life (PDQ39), and impairment (UPDRS part 3) (all p < 0.001). Algorithm-defined dependency status also predicted mortality: HR for mortality in those dependent vs independent at baseline was 1.6 (95%CI 1.2–2.1) and in those dependent vs independent at five-years’ follow-up was 2.2 (1.6–3.0). Discussion: We have demonstrated the concurrent validity, convergent validity, and predictive validity of a UPDRS-/MDS-UPDRS-based algorithm to define functional dependency in PD. This can be used for studying dependency in any study where UPDRS or MDS-UPDRS part 2 data have been collected. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartofpagefrom | 49 | |
dc.relation.ispartofpageto | 53 | |
dc.relation.ispartofjournal | Parkinsonism and Related Disorders | |
dc.relation.ispartofvolume | 76 | |
dc.subject.fieldofresearch | Clinical sciences | |
dc.subject.fieldofresearch | Cognitive and computational psychology | |
dc.subject.fieldofresearchcode | 3202 | |
dc.subject.fieldofresearchcode | 5204 | |
dc.title | Validation of a UPDRS-/MDS-UPDRS-based definition of functional dependency for Parkinson's disease | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | Ramsay, N; Macleod, AD; Alves, G; Camacho, M; Forsgren, L; Lawson, RA; Maple-Grødem, J; Tysnes, OB; Williams-Gray, CH; Yarnall, AJ; Counsell, CE; Rachael A Lawson, ; Guido Alves, S; Khoo, TK, Validation of a UPDRS-/MDS-UPDRS-based definition of functional dependency for Parkinson's disease, Parkinsonism and Related Disorders, 2020, 76, pp. 49-53 | |
dc.date.updated | 2020-11-04T03:49:51Z | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Khoo, Tien Kheng | |