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dc.contributor.authorBalmain, Bryce N
dc.contributor.authorSabapathy, Surendran
dc.contributor.authorYamada, Akira
dc.contributor.authorShiino, Kenji
dc.contributor.authorChan, Jonathan
dc.contributor.authorHaseler, Luke J
dc.contributor.authorKavanagh, Justin J
dc.contributor.authorMorris, Norman R
dc.contributor.authorStewart, Glenn M
dc.date.accessioned2020-11-05T02:59:15Z
dc.date.available2020-11-05T02:59:15Z
dc.date.issued2020
dc.identifier.issn0363-6135
dc.identifier.doi10.1152/ajpheart.00427.2020
dc.identifier.urihttp://hdl.handle.net/10072/398983
dc.description.abstractStrenuous exercise elicits transient functional and biochemical cardiac imbalances. Yet, the extent to which these responses are altered due to aging is unclear. Accordingly, echocardiograph-derived left (LV) and right (RV) ventricular global longitudinal strain (GLS), and high-sensitivity cardiac troponin I (hs-cTnI) were assessed before (pre) and after (post) a 60min high-intensity cycling race intervention (CRIT60) in 11 Young (18-30 y) and 11 Middle-aged (40-65 y) highly-trained male cyclists, matched for cardiorespiratory fitness. LV and RV GLS, were measured at rest and during a semi-recumbent exercise challenge performed at the same intensity (Young: 93±10; Middle-aged: 85±11 W, p=0.60) pre- and post-CRIT60. Augmentation (change from rest-to-exercise challenge) of LV GLS (pre: -2.97±0.65; post: -0.82±0.48%, p=0.02) and RV GLS (pre: -2.08±1.28; post: 3.08±2.02%, p=0.01) were attenuated and completely abolished, respectively, in Young following the CRIT60, while augmentation of LV GLS (pre: -3.21±0.41; post: -3.99±0.55%, p=0.22) and RV GLS (pre: -3.47±1.44; post: -1.26±1.00%, p=0.27) were preserved in Middle-aged following the CRIT60. While serum hs-cTnI increased following the CRIT60 in Young (pre: 7.3±1.6; post: 17.7±1.6ng/L, p<0.01) and Middle-aged (pre: 4.5±0.6; post: 10.7±2.0ng/L, p<0.01), hs-cTnI increased to a greater extent in Young compared to Middle-aged following CRIT60 (p<0.01). These findings suggest that functional and biochemical cardiac perturbations induced by high-intensity exercise are attenuated in Middle-aged relative to Young individuals. Further study is warranted to determine whether acute exercise-induced cardiac perturbations alter the adaptive myocardial remodeling response.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Physiological Society
dc.relation.ispartofjournalAmerican Journal of Physiology-Heart and Circulatory Physiology
dc.subject.fieldofresearchZoology
dc.subject.fieldofresearchMedical physiology
dc.subject.fieldofresearchCardiovascular medicine and haematology
dc.subject.fieldofresearchcode3109
dc.subject.fieldofresearchcode3208
dc.subject.fieldofresearchcode3201
dc.subject.keywordsAge
dc.subject.keywordsAthletes Heart
dc.subject.keywordsCardiac Troponin
dc.subject.keywordsEchocardiography
dc.subject.keywordsRemodelling
dc.titleCardiac perturbations after high-intensity exercise are attenuated in middle-aged compared to young endurance athletes: diminished stress or depleted stimuli?
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationBalmain, BN; Sabapathy, S; Yamada, A; Shiino, K; Chan, J; Haseler, LJ; Kavanagh, JJ; Morris, NR; Stewart, GM, Cardiac perturbations after high-intensity exercise are attenuated in middle-aged compared to young endurance athletes: diminished stress or depleted stimuli?, American Journal of Physiology-Heart and Circulatory Physiology, 2020
dc.date.updated2020-11-05T01:24:21Z
dc.description.versionAccepted Manuscript (AM)
gro.description.notepublicThis publication has been entered in Griffith Research Online as an advanced online version.
gro.rights.copyright© 2020 American Physiological Society . This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorChan, Jonathan H.
gro.griffith.authorKavanagh, Justin J.
gro.griffith.authorSabapathy, Surendran
gro.griffith.authorMorris, Norman


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