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dc.contributor.authorQ. Liu, Xue
dc.contributor.authorN. J. Hart, Derek
dc.contributor.authorG. MacPherson, Gordon
dc.contributor.authorF. Good, Michael
dc.contributor.authorN. Wykes, Michelle
dc.date.accessioned2017-05-03T14:54:52Z
dc.date.available2017-05-03T14:54:52Z
dc.date.issued2008
dc.date.modified2011-08-12T06:19:49Z
dc.identifier.issn00192805
dc.identifier.doi10.1111/j.1365-2567.2008.02914.x
dc.identifier.urihttp://hdl.handle.net/10072/39909
dc.description.abstractThe development and maintenance of memory B cells (MBC) is dependent on germinal centres (GC) with follicular dendritic cell (FDC) networks. We have previously shown that FDC networks within GC of the spleen express a novel ligand for CD38 and that the administration of soluble CD38 induces an expansion of these cellular structures. We therefore used adoptive transfer studies to investigate whether the expansion of FDC networks with soluble CD38 affected the generation and maintenance of antigen-specific MBC. These studies found that the administration of soluble CD38 significantly extended the period after which MBC could be activated and that the frequencies of these cells also were increased. In conclusion, soluble CD38 appears to significantly extend the lifespan of antibody memory by increasing the numbers of MBC.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoen_AU
dc.publisherWiley-Blackwell Publishing Ltd.
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom14
dc.relation.ispartofpageto20
dc.relation.ispartofissue1
dc.relation.ispartofjournalImmunology
dc.relation.ispartofvolume125
dc.rights.retentionY
dc.subject.fieldofresearchImmunology not elsewhere classified
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchPaediatrics and Reproductive Medicine
dc.subject.fieldofresearchcode110799
dc.subject.fieldofresearchcode1107
dc.subject.fieldofresearchcode1114
dc.titleSoluble CD38 significantly prolongs the lifespan of memory B-cell responses
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2008
gro.hasfulltextNo Full Text
gro.griffith.authorGood, Michael F.


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