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dc.contributor.authorQ. Liu, Xueen_US
dc.contributor.authorN. J. Hart, Dereken_US
dc.contributor.authorG. MacPherson, Gordonen_US
dc.contributor.authorF. Good, Michaelen_US
dc.contributor.authorN. Wykes, Michelleen_US
dc.date.accessioned2017-05-03T14:54:52Z
dc.date.available2017-05-03T14:54:52Z
dc.date.issued2008en_US
dc.date.modified2011-08-12T06:19:49Z
dc.identifier.issn00192805en_US
dc.identifier.doi10.1111/j.1365-2567.2008.02914.xen_AU
dc.identifier.urihttp://hdl.handle.net/10072/39909
dc.description.abstractThe development and maintenance of memory B cells (MBC) is dependent on germinal centres (GC) with follicular dendritic cell (FDC) networks. We have previously shown that FDC networks within GC of the spleen express a novel ligand for CD38 and that the administration of soluble CD38 induces an expansion of these cellular structures. We therefore used adoptive transfer studies to investigate whether the expansion of FDC networks with soluble CD38 affected the generation and maintenance of antigen-specific MBC. These studies found that the administration of soluble CD38 significantly extended the period after which MBC could be activated and that the frequencies of these cells also were increased. In conclusion, soluble CD38 appears to significantly extend the lifespan of antibody memory by increasing the numbers of MBC.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherWiley-Blackwell Publishing Ltd.en_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom14en_US
dc.relation.ispartofpageto20en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalImmunologyen_US
dc.relation.ispartofvolume125en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchImmunology not elsewhere classifieden_US
dc.subject.fieldofresearchcode110799en_US
dc.titleSoluble CD38 significantly prolongs the lifespan of memory B-cell responsesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2008
gro.hasfulltextNo Full Text


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