Show simple item record

dc.contributor.authorSwarbrick, CMD
dc.contributor.authorNanson, JD
dc.contributor.authorPatterson, EI
dc.contributor.authorForwood, JK
dc.date.accessioned2020-11-11T00:53:59Z
dc.date.available2020-11-11T00:53:59Z
dc.date.issued2020
dc.identifier.issn0163-7827
dc.identifier.doi10.1016/j.plipres.2020.101036
dc.identifier.urihttp://hdl.handle.net/10072/399184
dc.description.abstractThioesterases are present in all living cells and perform a wide range of important biological functions by catalysing the cleavage of thioester bonds present in a diverse array of cellular substrates. Thioesterases are organised into 25 families based on their sequence conservation, tertiary and quaternary structure, active site configuration, and substrate specificity. Recent structural and functional characterisation of thioesterases has led to significant changes in our understanding of the regulatory mechanisms that govern enzyme activity and their respective cellular roles. The resulting dogma changes in thioesterase regulation include mechanistic insights into ATP and GDP-mediated regulation by oligomerisation, the role of new key regulatory regions, and new insights into a conserved quaternary structure within TE4 family members. Here we provide a current and comparative snapshot of our understanding of thioesterase structure, function, and regulation across the different thioesterase families.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom101036
dc.relation.ispartofjournalProgress in Lipid Research
dc.relation.ispartofvolume79
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchMedical biochemistry and metabolomics
dc.subject.fieldofresearchNutrition and dietetics
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3205
dc.subject.fieldofresearchcode3210
dc.subject.keywordsCoenzyme A
dc.subject.keywordsFatty acyl-CoA
dc.subject.keywordsHotdog domain
dc.subject.keywordsHydrolase
dc.subject.keywordsRegulation
dc.titleStructure, function, and regulation of thioesterases
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationSwarbrick, CMD; Nanson, JD; Patterson, EI; Forwood, JK, Structure, function, and regulation of thioesterases, Progress in Lipid Research, 2020, 79, pp. 101036-
dcterms.dateAccepted2020-05-01
dc.date.updated2020-11-11T00:44:58Z
gro.hasfulltextNo Full Text
gro.griffith.authorSwarbrick, Crystall


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record