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dc.contributor.authorSwarbrick, CMD
dc.contributor.authorNanson, JD
dc.contributor.authorPatterson, EI
dc.contributor.authorForwood, JK
dc.date.accessioned2020-11-11T00:53:59Z
dc.date.available2020-11-11T00:53:59Z
dc.date.issued2020
dc.identifier.issn0163-7827en_US
dc.identifier.doi10.1016/j.plipres.2020.101036en_US
dc.identifier.urihttp://hdl.handle.net/10072/399184
dc.description.abstractThioesterases are present in all living cells and perform a wide range of important biological functions by catalysing the cleavage of thioester bonds present in a diverse array of cellular substrates. Thioesterases are organised into 25 families based on their sequence conservation, tertiary and quaternary structure, active site configuration, and substrate specificity. Recent structural and functional characterisation of thioesterases has led to significant changes in our understanding of the regulatory mechanisms that govern enzyme activity and their respective cellular roles. The resulting dogma changes in thioesterase regulation include mechanistic insights into ATP and GDP-mediated regulation by oligomerisation, the role of new key regulatory regions, and new insights into a conserved quaternary structure within TE4 family members. Here we provide a current and comparative snapshot of our understanding of thioesterase structure, function, and regulation across the different thioesterase families.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom101036en_US
dc.relation.ispartofjournalProgress in Lipid Researchen_US
dc.relation.ispartofvolume79en_US
dc.subject.fieldofresearchBiochemistry and Cell Biologyen_US
dc.subject.fieldofresearchMedical Biochemistry and Metabolomicsen_US
dc.subject.fieldofresearchNutrition and Dieteticsen_US
dc.subject.fieldofresearchcode0601en_US
dc.subject.fieldofresearchcode1101en_US
dc.subject.fieldofresearchcode1111en_US
dc.subject.keywordsCoenzyme Aen_US
dc.subject.keywordsFatty acyl-CoAen_US
dc.subject.keywordsHotdog domainen_US
dc.subject.keywordsHydrolaseen_US
dc.subject.keywordsRegulationen_US
dc.titleStructure, function, and regulation of thioesterasesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationSwarbrick, CMD; Nanson, JD; Patterson, EI; Forwood, JK, Structure, function, and regulation of thioesterases, Progress in Lipid Research, 2020, 79, pp. 101036-en_US
dcterms.dateAccepted2020-05-01
dc.date.updated2020-11-11T00:44:58Z
gro.hasfulltextNo Full Text
gro.griffith.authorSwarbrick, Crystall


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