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  • Anaplastic thyroid carcinoma: Updates on WHO classification, clinicopathological features and staging

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    Author(s)
    Abe, Ichiro
    Lam, Alfred King-Yin
    Griffith University Author(s)
    Lam, Alfred K.
    Year published
    2020
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    Abstract
    Anaplastic thyroid carcinoma is an uncommon carcinoma representing 1 to 4 % of all thyroid cancers. The carcinoma is most common in females of the eight decades. It is a locally advanced cancer with frequent infiltration of surrounding organs, blood vessels and skin of neck. Paraneoplastic manifestations could occur. Approximately half of the patients with anaplastic thyroid carcinoma had distant metastasis with lung and brain as the most frequent sites of metastasis. The median survival of patients with anaplastic thyroid carcinoma reported was from 1 to 6 months. The current terminology of the cancer in World Health ...
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    Anaplastic thyroid carcinoma is an uncommon carcinoma representing 1 to 4 % of all thyroid cancers. The carcinoma is most common in females of the eight decades. It is a locally advanced cancer with frequent infiltration of surrounding organs, blood vessels and skin of neck. Paraneoplastic manifestations could occur. Approximately half of the patients with anaplastic thyroid carcinoma had distant metastasis with lung and brain as the most frequent sites of metastasis. The median survival of patients with anaplastic thyroid carcinoma reported was from 1 to 6 months. The current terminology of the cancer in World Health Organization is "anaplastic thyroid carcinoma" rather than "undifferentiated thyroid carcinoma". In the latest American Joint Committee on Cancer (AJCC) TNM staging system for anaplastic thyroid carcinoma, there are updates on T and N categories. To conclude, updated knowledge of clinicopathological features, classification, pathological staging will improve our understanding of the cancer and will help in the management of the patients with this aggressive cancer.
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    Journal Title
    Histology and Histopathology
    DOI
    https://doi.org/10.14670/HH-18-277
    Copyright Statement
    © 2020 Universidad de Murcia. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Note
    This publication has been entered into Griffith Research Online as an Advanced Online Version.
    Subject
    Clinical sciences
    Publication URI
    http://hdl.handle.net/10072/399228
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    • Journal articles

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