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dc.contributor.authorM. Abdel-Aal, Abu-Bakeren_US
dc.contributor.authorR. Batzloff, Michaelen_US
dc.contributor.authorFujita, Yoshioen_US
dc.contributor.authorBarozzi, Nadiaen_US
dc.contributor.authorFaria, Andresen_US
dc.contributor.authorSimerska, Pavlaen_US
dc.contributor.authorM. Moyle, Peteren_US
dc.contributor.authorF. Good, Michaelen_US
dc.contributor.authorToth, Istvanen_US
dc.date.accessioned2017-05-03T14:54:47Z
dc.date.available2017-05-03T14:54:47Z
dc.date.issued2008en_US
dc.date.modified2011-08-12T06:20:19Z
dc.identifier.issn00222623en_US
dc.identifier.doi10.1021/jm701091den_AU
dc.identifier.urihttp://hdl.handle.net/10072/39924
dc.description.abstractThe development of 16 self-adjuvanting group A streptococcal vaccine candidates, composed of (i) a universal helper T-cell epitope (P25), (ii) a target GAS B-cell epitope (J14), and (iii) a lipid moiety, is described. Systemic J14-specific IgG antibodies were detected following subcutaneous immunization of BALB/c (H-2d) mice with each construct without the need for an additional adjuvant. The effect of changing the order of P25, J14, and lipid moiety attachment or incorporation of P25 and J14 into a lipid-core peptide system on antibody titers was assessed. The point of lipid moiety attachment had the greatest influence on systemic J14-specific IgG antibody titers. Overall, the best vaccines featured a C-terminal lipid moiety, conjugated through a lysine residue to P25 at the N-terminus, and J14 on the lysine side chain.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherAmerican Chemical Societyen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom167en_US
dc.relation.ispartofpageto172en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalJournal of Medicinal Chemistryen_US
dc.relation.ispartofvolume51en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry not elsewhere classifieden_US
dc.subject.fieldofresearchcode030499en_US
dc.titleStructure–Activity Relationship of a Series of Synthetic Lipopeptide Self-Adjuvanting Group A Streptococcal Vaccine Candidatesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.en_AU
gro.date.issued2008
gro.hasfulltextNo Full Text


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