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dc.contributor.authorGood, Michaelen_US
dc.contributor.authorPinzon-Charry, Albertoen_US
dc.date.accessioned2017-04-04T20:30:55Z
dc.date.available2017-04-04T20:30:55Z
dc.date.issued2008en_US
dc.date.modified2011-08-12T06:20:21Z
dc.identifier.issn14712598en_US
dc.identifier.urihttp://hdl.handle.net/10072/39925
dc.description.abstractBackground: Malaria is a significant health problem causing morbidity and mortality worldwide. Vaccine development has been an imperative for decades. However, the intricacy of the parasite's lifecycle coupled with the lack of evidence for robust infection-induced immunity has made vaccine development exceptionally difficult. Objective: To review some of the key advances in the field and discuss potential ways forward for a whole-organism vaccine. Methods: The authors searched PubMed using the words 'malaria and vaccine'. We searched for manuscripts detailing antigen characterisation and vaccine strategies with emphasis on subunit versus whole-parasite approaches. Abstracts were selected and relevant articles are discussed. The searches were not restricted by language or date. Conclusions: The early cloning of malaria antigens has fuelled rapid development of subunit vaccines. However, the disappointing results of clinical trials have resulted in reappraisal of current strategies. Whole-parasite approaches have re-emerged as an alternative strategy. Immunization using radiation or genetically attenuated sporozoites has been shown to result in sterile immunity and immunization with blood-stage parasites curtailed by antimalarials has demonstrated delayed parasitemia in rodent models as well as in human malaria.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherInforma Healthcareen_US
dc.publisher.placeUnited Kingdomen_US
dc.publisher.urihttp://informahealthcare.com/doi/abs/10.1517/14712598.8.4.441en_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom441en_US
dc.relation.ispartofpageto448en_US
dc.relation.ispartofissue4en_AU
dc.relation.ispartofjournalExpert Opinion on Biological Therapyen_US
dc.relation.ispartofvolume8en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classifieden_US
dc.subject.fieldofresearchcode119999en_US
dc.titleMalaria vaccines: the case for a whole-organism approachen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2008
gro.hasfulltextNo Full Text


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