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dc.contributor.authorPinzon-Charry, Alberto
dc.contributor.authorGood, Michael F
dc.date.accessioned2017-05-03T14:54:50Z
dc.date.available2017-05-03T14:54:50Z
dc.date.issued2008
dc.date.modified2011-08-12T06:20:21Z
dc.identifier.issn1471-2598
dc.identifier.urihttp://hdl.handle.net/10072/39925
dc.description.abstractBackground: Malaria is a significant health problem causing morbidity and mortality worldwide. Vaccine development has been an imperative for decades. However, the intricacy of the parasite's lifecycle coupled with the lack of evidence for robust infection-induced immunity has made vaccine development exceptionally difficult. Objective: To review some of the key advances in the field and discuss potential ways forward for a whole-organism vaccine. Methods: The authors searched PubMed using the words 'malaria and vaccine'. We searched for manuscripts detailing antigen characterisation and vaccine strategies with emphasis on subunit versus whole-parasite approaches. Abstracts were selected and relevant articles are discussed. The searches were not restricted by language or date. Conclusions: The early cloning of malaria antigens has fuelled rapid development of subunit vaccines. However, the disappointing results of clinical trials have resulted in reappraisal of current strategies. Whole-parasite approaches have re-emerged as an alternative strategy. Immunization using radiation or genetically attenuated sporozoites has been shown to result in sterile immunity and immunization with blood-stage parasites curtailed by antimalarials has demonstrated delayed parasitemia in rodent models as well as in human malaria.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoen_AU
dc.publisherInforma Healthcare
dc.publisher.placeUnited Kingdom
dc.publisher.urihttp://informahealthcare.com/doi/abs/10.1517/14712598.8.4.441
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom441
dc.relation.ispartofpageto448
dc.relation.ispartofissue4
dc.relation.ispartofjournalExpert Opinion on Biological Therapy
dc.relation.ispartofvolume8
dc.rights.retentionY
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classified
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode119999
dc.subject.fieldofresearchcode11
dc.titleMalaria vaccines: the case for a whole-organism approach
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2008
gro.hasfulltextNo Full Text
gro.griffith.authorGood, Michael F.


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