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  • Prospective Surveillance of Invasive Group A Streptococcal Disease, Fiji, 2005–2007

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    SteerPUB415.pdf (184.8Kb)
    Author(s)
    Steer, Andrew C.
    Jenney, Adam
    Kado, Joseph
    Good, Michael F.
    Batzloff, Michael
    Waqatakirewa, Lepani
    Kim Mullholland, E.
    Carapetis, Jonathan R.
    Griffith University Author(s)
    Good, Michael F.
    Year published
    2009
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    Abstract
    We undertook a prospective active surveillance study of invasive group A streptococcal (GAS) disease in Fiji over a 23-month period, 2005-2007. We identified 64 cases of invasive GAS disease, which represents an average annualized all-ages incidence of 9.9 cases/100,000 population per year (95% confidence interval [CI] 7.6-12.6). Rates were highest in those >65 years of age and in those <5 years, particularly in infants, for whom the incidence was 44.9/100,000 (95% CI 18.1-92.5). The case-fatality rate was 32% and was associated with increasing age and underlying coexisting disease, including diabetes and renal disease. ...
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    We undertook a prospective active surveillance study of invasive group A streptococcal (GAS) disease in Fiji over a 23-month period, 2005-2007. We identified 64 cases of invasive GAS disease, which represents an average annualized all-ages incidence of 9.9 cases/100,000 population per year (95% confidence interval [CI] 7.6-12.6). Rates were highest in those >65 years of age and in those <5 years, particularly in infants, for whom the incidence was 44.9/100,000 (95% CI 18.1-92.5). The case-fatality rate was 32% and was associated with increasing age and underlying coexisting disease, including diabetes and renal disease. Fifty-five of the GAS isolates underwent emm sequence typing; the types were highly diverse, with 38 different emm subtypes and no particular dominant type. Our data support the view that invasive GAS disease is common in developing countries and deserves increased public health attention.
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    Journal Title
    Emerging Infectious Diseases
    Volume
    15
    Issue
    2
    DOI
    https://doi.org/10.3201/eid1502.080558
    Copyright Statement
    © 2009 Centers for Disease Control and Prevention. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Biological Sciences not elsewhere classified
    Clinical Sciences
    Medical Microbiology
    Public Health and Health Services
    Publication URI
    http://hdl.handle.net/10072/39927
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    • Journal articles

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