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dc.contributor.authorJeste, SS
dc.contributor.authorWu, JY
dc.contributor.authorSenturk, D
dc.contributor.authorVarcin, K
dc.contributor.authorKo, J
dc.contributor.authorMcCarthy, B
dc.contributor.authorShimizu, C
dc.contributor.authorDies, K
dc.contributor.authorVogel-Farley, V
dc.contributor.authorSahin, M
dc.contributor.authorNelson, CA
dc.description.abstractAAN PUBLICATIONS Skip to main content Advertisement Journals Specialty Sites Collections Podcast CME About Authors Search for this keyword search Advanced Search Home The most widely read and highly cited peer-reviewed neurology journal Subscribe My Alerts Log in Site Logo Home Latest Articles Current Issue Past Issues Residents & Fellows SHARE July 08, 2014; 83 (2) ARTICLE Early developmental trajectories associated with ASD in infants with tuberous sclerosis complex Shafali Spurling Jeste, Joyce Y. Wu, Damla Senturk, Kandice Varcin, Jordan Ko, Brigid McCarthy, Christina Shimizu, Kira Dies, Vanessa Vogel-Farley, Mustafa Sahin, Charles A. Nelson First published June 11, 2014, DOI: FULL PDF CITATION PERMISSIONS MAKE COMMENT SEE COMMENTS Article has an altmetric score of 11 Downloads707 Add to Cart ($39) Article Figures & Data Info & Disclosures This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased. Abstract Objective: We performed a longitudinal cohort study of infants with tuberous sclerosis complex (TSC), with the overarching goal of defining early clinical, behavioral, and biological markers of autism spectrum disorder (ASD) in this high-risk population. Methods: Infants with TSC and typically developing controls were recruited as early as 3 months of age and followed longitudinally until 36 months of age. Data gathered at each time point included detailed seizure history, developmental testing using the Mullen Scales of Early Learning, and social-communication assessments using the Autism Observation Scale for Infants. At 18 to 36 months, a diagnostic evaluation for ASD was performed using the Autism Diagnostic Observation Schedule. Results: Infants with TSC demonstrated delays confined to nonverbal abilities, particularly in the visual domain, which then generalized to more global delays by age 9 months. Twenty-two of 40 infants with TSC were diagnosed with ASD. Both 12-month cognitive ability and developmental trajectories over the second and third years of life differentiated the groups. By 12 months of age, the ASD group demonstrated significantly greater cognitive delays and a significant decline in nonverbal IQ from 12 to 36 months. Conclusions: This prospective study characterizes early developmental markers of ASD in infants with TSC. The early delay in visual reception and fine motor ability in the TSC group as a whole, coupled with the decline in nonverbal ability in infants diagnosed with ASD, suggests a domain-specific pathway to ASD that can inform more targeted interventions for these high-risk infants.en_US
dc.publisherOvid Technologies (Wolters Kluwer Health)en_US
dc.subject.fieldofresearchClinical Sciencesen_US
dc.subject.fieldofresearchCognitive Sciencesen_US
dc.titleEarly developmental trajectories associated with ASD in infants with tuberous sclerosis complexen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationJeste, SS; Wu, JY; Senturk, D; Varcin, K; Ko, J; McCarthy, B; Shimizu, C; Dies, K; Vogel-Farley, V; Sahin, M; Nelson, CA, Early developmental trajectories associated with ASD in infants with tuberous sclerosis complex, Neurology, 2014, 83 (2), pp. 160-168en_US
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gro.griffith.authorVarcin, Kandice J.

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