dc.contributor.author | Cubo, Leticia | |
dc.contributor.author | Thomas, Donald S | |
dc.contributor.author | Zhang, Junyong | |
dc.contributor.author | Quiroga, Adoracion G | |
dc.contributor.author | Navarro-Ranninger, Carmen | |
dc.contributor.author | Berners-Price, Susan J | |
dc.date.accessioned | 2018-02-13T03:27:24Z | |
dc.date.available | 2018-02-13T03:27:24Z | |
dc.date.issued | 2009 | |
dc.date.modified | 2011-08-12T06:20:30Z | |
dc.identifier.issn | 0020-1693 | |
dc.identifier.doi | 10.1016/j.ica.2008.03.117 | |
dc.identifier.uri | http://hdl.handle.net/10072/39931 | |
dc.description.abstract | Two 15N-labelled cis-Pt(II) diamine complexes with dimethylamine (15N-dma) and isopropylamine (15N-ipa) ligands have been prepared and characterised. [1H,15N] HSQC NMR spectroscopy is used to obtain the rate and equilibrium constants for the aquation of cis-[PtCl2(15N-dma)2] at 298 K in 0.1 M NaClO4 and to determine the pKa values of cis-[PtCl(H2O)(15N-dma)2]+ (6.37) and cis-[Pt(H2O)2(15N-dma)2]2+ (pKa1 = 5.17, pKa2 = 6.47). The rate constants for the first and second aquation steps (k1 = (2.12 ᠰ.01) נ10-5 s-1, k2 = (8.7 ᠰ.7) נ10-6 s-1) and anation steps (k-1 = (6.7 ᠰ.8) נ10-3 M-1 s-1, k-2 = 0.043 ᠰ.004 M-1 s-1) are very similar to those reported for cisplatin under similar conditions, and a minor difference is that slow formation of the hydroxo-bridged dimer is observed. Aquation studies of cis-[PtCl2(15N-ipa)2] were precluded by the close proximity of the NH proton signal to the 1H2O resonance. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.publisher.place | Netherlands | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 1022 | |
dc.relation.ispartofpageto | 1026 | |
dc.relation.ispartofissue | 3 | |
dc.relation.ispartofjournal | Inorganica Chimica Acta | |
dc.relation.ispartofvolume | 362 | |
dc.relation.uri | http://purl.org/au-research/grants/ARC/DP0662817 | |
dc.relation.grantID | DP0662817 | |
dc.relation.funders | ARC | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Inorganic chemistry | |
dc.subject.fieldofresearch | Inorganic chemistry not elsewhere classified | |
dc.subject.fieldofresearch | Physical chemistry | |
dc.subject.fieldofresearch | Other chemical sciences | |
dc.subject.fieldofresearchcode | 3402 | |
dc.subject.fieldofresearchcode | 340299 | |
dc.subject.fieldofresearchcode | 3406 | |
dc.subject.fieldofresearchcode | 3499 | |
dc.title | [1H,15N] NMR studies of the aquation of cis-diamine platinum(II) complexes | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2009 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Berners-Price, Sue J. | |