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  • What really happens to dendritic cells during malaria?

    Author(s)
    N. Wykes, Michelle
    F. Good, Michael
    Griffith University Author(s)
    Good, Michael F.
    Year published
    2008
    Metadata
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    Abstract
    As dendritic cells (DCs) initiate all adaptive and some innate immune responses, it is not surprising that DC function during malaria is the subject of intensive investigations. However, the results of these investigations have so far been controversial. Here, we discuss various aspects of these studies, including the influence of the species and strain of Plasmodium on DC function, the effects of Plasmodium infection on the activation of CD8+ T cells by DCs, the effects of haemozoin and the effects of Plasmodium infections on DC Toll-like-receptor signalling.As dendritic cells (DCs) initiate all adaptive and some innate immune responses, it is not surprising that DC function during malaria is the subject of intensive investigations. However, the results of these investigations have so far been controversial. Here, we discuss various aspects of these studies, including the influence of the species and strain of Plasmodium on DC function, the effects of Plasmodium infection on the activation of CD8+ T cells by DCs, the effects of haemozoin and the effects of Plasmodium infections on DC Toll-like-receptor signalling.
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    Journal Title
    Nature Reviews Microbiology
    Volume
    6
    Issue
    11
    DOI
    https://doi.org/10.1038/nrmicro1988
    Subject
    Microbiology not elsewhere classified
    Microbiology
    Medical Microbiology
    Publication URI
    http://hdl.handle.net/10072/39939
    Collection
    • Journal articles

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