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  • Elevated maternal linoleic acid alters placental fatty acids, nutrient transporters and inflammatory proteins

    Author(s)
    Hryciw, Deanne
    Shrestha, Nirajan
    Sleep, Simone
    Cuffe, James
    Holland, Olivia
    Perkins, Anthony
    McAinch, Andrew
    Griffith University Author(s)
    Hryciw, D
    Holland, Olivia J.
    Hryciw, Deanne
    Year published
    2020
    Metadata
    Show full item record
    Abstract
    Linoleic acid (LA) is the major omega‐6 fatty acid which is obtained from our diet. During pregnancy, LA is required for adequate fetal growth and development. For the growing fetus LA can only be obtained from the maternal diet, and is transferred from the maternal to fetal circulations by the placenta. At this time, in Western societies, we are overconsuming LA during pregnancy. Omega‐6 is metabolised by FADS1 and FADS2, which also metabiolise omega‐3. The ratio of omega‐6 to omega‐3 is important for human health, as they are proinflammatory and anti‐inflammatory, respectively. Therefore, the aim of this study is to determine ...
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    Linoleic acid (LA) is the major omega‐6 fatty acid which is obtained from our diet. During pregnancy, LA is required for adequate fetal growth and development. For the growing fetus LA can only be obtained from the maternal diet, and is transferred from the maternal to fetal circulations by the placenta. At this time, in Western societies, we are overconsuming LA during pregnancy. Omega‐6 is metabolised by FADS1 and FADS2, which also metabiolise omega‐3. The ratio of omega‐6 to omega‐3 is important for human health, as they are proinflammatory and anti‐inflammatory, respectively. Therefore, the aim of this study is to determine if elevated maternal LA during pregnancy is alters placental fatty acids, nutrient transporter gene expression and inflammatory proteins. Female Wistar Kyoto rats were fed a diet low in LA (LLA‐1.44% of energy) or diet high in LA (HLA‐6.21% of energy) for 10 weeks before and during gestation. Following mating with a male consuming normal chow, offspring and maternal rats were sacrificed at embryonic day (E)20, and placenta were collected for analysis of placental fatty acids, nutrient transporters and inflammatory markers. In isolated placenta from pregnancies where mothers consumed an elevated LA diet, the concentration of LA was increased and the concentration of the omega‐3 fatty acid a‐linoleinic acid was decreased. Of interest, the downstream metabolite of LA, arachidonic acid was not altered in placenta from mothers consuming an elevated LA diet. mRNA expression of slc27a1 (fatty acid trasnport protein 1) was significantly downregulated in the male placenta from the dams fed with HLA, but not females. The mRNA expression of slc2a1 (glucose trasnporter 1) was significantly decreased in both male and female placenta from mothers fed the HLA diet. Further, the protein concentration of interleukin‐7 (IL‐7) was significantly decreased in both male and female placenta (labyrinth) from the dams fed with HLA, however there were no changes in protein expression of IL‐6 and TNF‐α in the labyrinth. In conclusion, a maternal diet high in LA alters fatty acid concentrations, nutrient transporters and inflammatory cytokines in the placenta. The consequences of this on offspring development, and therefore long term health require further investigation.
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    Conference Title
    The FASEB Journal
    Volume
    34
    Issue
    S1
    DOI
    https://doi.org/10.1096/fasebj.2020.34.s1.03732
    Subject
    Biochemistry and cell biology
    Zoology
    Medical physiology
    Science & Technology
    Life Sciences & Biomedicine
    Biology
    Molecular Biology
    Publication URI
    http://hdl.handle.net/10072/399461
    Collection
    • Conference outputs

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