Multi-agent modeling simulation of in-vitro T-cells for immunologic alternatives to cancer treatment

Abstract

There is exciting news in recent developments suggesting the potential to treat some human cancers by stimulating the patients own immune system. However, there is still much to understand; therefore, modelling the battle between those cells that are constituents of the human immune system against tumorous cells can significantly provide insights as mathematical modelling has done regarding the immune system behaviour against virus infections. In this paper we innovate in two directions. First, we move the modelling of immune struggles from the sphere of ordinary-differential equation models to the modelling by multi-agent simulations. We highlight the advantages of the multi-agent simulation, for example the consideration of elaborate spatial proximity interactions. Secondly, we move away from the realm of infectious diseases to the complex modelling of the stimulation of T-cells and their participation in fighting cancerous cell tumours.