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  • Antiplasmodial Alkaloids from the Australian Bryozoan Amathia lamourouxi

    Author(s)
    Kleks, G
    Holland, DC
    Kennedy, EK
    Avery, VM
    Carroll, AR
    Griffith University Author(s)
    Carroll, Anthony R.
    Holland, Darren C.
    Kleks, Guy
    Kennedy, Emily K.
    Avery, Vicky M.
    Year published
    2020
    Metadata
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    Abstract
    An extract from the bryozoan Amathia lamourouxi with antiplasmodial activity was identified through high-throughput screening of an Australian marine invertebrate extract library against Plasmodium falciparum. Chemical investigation of A. lamourouxi resulted in the isolation of six new brominated alkaloids, convolutamines K and L (1 and 2), volutamides F-H (3-5), and 2,5-dibromo-1-methyl-1H-indole-3-carbaldehyde (6). Three of the compounds (2-4) displayed moderate to potent antiplasmodial activity against both the chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) parasite strains of Plasmodium falciparum with an ...
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    An extract from the bryozoan Amathia lamourouxi with antiplasmodial activity was identified through high-throughput screening of an Australian marine invertebrate extract library against Plasmodium falciparum. Chemical investigation of A. lamourouxi resulted in the isolation of six new brominated alkaloids, convolutamines K and L (1 and 2), volutamides F-H (3-5), and 2,5-dibromo-1-methyl-1H-indole-3-carbaldehyde (6). Three of the compounds (2-4) displayed moderate to potent antiplasmodial activity against both the chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) parasite strains of Plasmodium falciparum with an IC50 range of 0.57-1.7 μM and a high selectivity index against a human cell line (HEK293).
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    Journal Title
    Journal of Natural Products
    DOI
    https://doi.org/10.1021/acs.jnatprod.0c00929
    Note
    This publication has been entered as an advanced online version in Griffith Research Online.
    Subject
    Chemical sciences
    Biological sciences
    Biomedical and clinical sciences
    Publication URI
    http://hdl.handle.net/10072/399616
    Collection
    • Journal articles

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