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dc.contributor.authorDi Giuseppe, Giancarlo
dc.contributor.authorYoulden, Danny R
dc.contributor.authorAitken, Joanne F
dc.contributor.authorPole, Jason D
dc.date.accessioned2022-03-23T01:39:16Z
dc.date.available2022-03-23T01:39:16Z
dc.date.issued2020
dc.identifier.issn0008-543X
dc.identifier.doi10.1002/cncr.33319
dc.identifier.urihttp://hdl.handle.net/10072/399694
dc.description.abstractBackground: Pediatric hepatic cancer is a rare malignancy, comprising only approximately 2% of all cancers diagnosed in children aged <15 years. The authors sought to describe trends in pediatric hepatic cancer incidence and survival in Ontario, Canada; the United States; and Australia. Methods: Children aged <15 years who were diagnosed with hepatic cancer from 1985 through 2013 were ascertained through population-based registries and followed from the time of diagnosis until December 31, 2015. Age-standardized incidence and 5-year relative survival were calculated for each jurisdiction. Multivariable flexible parametric survival models were used to explore predictors of hepatic cancer mortality. Results: A total of 794 children were identified in Ontario (148 children), the United States (400 children), and Australia (246 children). The average annual incidence increased by 2.2% (95% CI, 0.5%-4.0%) in Australia, 2.1% (95% CI, 0.9%-3.3%) in the United States, and 1.3% (95% CI, -0.4% to 3.0%) in Ontario. The 5-year relative survival rate improved from 60% to 82% (P = .08) in Ontario and 62% to 78% (P = .02) in the United States between the diagnostic periods 1985 through 1994 and 2005 through 2013, whereas in Australia the rate remained constant (between 74% and 77%) during the study period. On multivariable analysis, there was no significant difference noted with regard to the hazard of death between jurisdictions (P = .06). Older age, the presence of metastatic disease, and being diagnosed with hepatocellular carcinoma were found to be associated with mortality. Conclusions: The incidence of hepatic cancer in children appears to have increased over the last 30 years in Australia and North America. Survival differences between Australia; Ontario, Canada; and the United States observed in the 1980s and 1990s were no longer apparent and only marginal geographical differences in the hazard of mortality were observed.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofpagefrom769
dc.relation.ispartofpageto776
dc.relation.ispartofissue5
dc.relation.ispartofjournalCancer
dc.relation.ispartofvolume127
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchHealth services and systems
dc.subject.fieldofresearchPublic health
dc.subject.fieldofresearchcode3211
dc.subject.fieldofresearchcode4203
dc.subject.fieldofresearchcode4206
dc.subject.keywordsAustralia
dc.subject.keywordsNorth America
dc.subject.keywordschildhood hepatic cancer
dc.subject.keywordsepidemiology
dc.subject.keywordsincidence
dc.titlePediatric hepatic cancer incidence and survival: 30-year trends in Ontario, Canada; the United States; and Australia
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationDi Giuseppe, G; Youlden, DR; Aitken, JF; Pole, JD, Pediatric hepatic cancer incidence and survival: 30-year trends in Ontario, Canada; the United States; and Australia., Cancer, 2021, 127 (5), pp. 769-776
dcterms.dateAccepted2020-10-21
dc.date.updated2020-11-26T02:01:17Z
dc.description.versionAccepted Manuscript (AM)
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.rights.copyright© 2021 American Cancer Society. This is the peer reviewed version of the following article: Pediatric hepatic cancer incidence and survival: 30-year trends in Ontario, Canada; the United States; and Australia., Cancer, 2021, 127 (5), pp. 769-776, which has been published in final form at https://doi.org/10.1002/cncr.33319. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
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gro.griffith.authorYoulden, Danny R.
gro.griffith.authorAitken, Joanne


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