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dc.contributor.authorZhang, Cheng
dc.contributor.authorMoonshi, Shehzahdi Shebbrin
dc.contributor.authorWang, Wenqian
dc.contributor.authorHang, Thu Ta
dc.contributor.authorHan, Yanxiao
dc.contributor.authorHan, Felicity Y
dc.contributor.authorPeng, Hui
dc.contributor.authorKral, Petr
dc.contributor.authorRolfe, Barbara E
dc.contributor.authorGooding, John Justin
dc.contributor.authorGaus, Katharina
dc.contributor.authorWhittaker, Andrew Keith
dc.date.accessioned2020-11-27T04:25:33Z
dc.date.available2020-11-27T04:25:33Z
dc.date.issued2018
dc.identifier.issn1936-0851
dc.identifier.doi10.1021/acsnano.8b03726
dc.identifier.urihttp://hdl.handle.net/10072/399735
dc.description.abstractTwo important challenges in the field of 19F magnetic resonance imaging (MRI) are the maintenance of high fluorine content without compromising imaging performance, and effective targeting of small particles to diseased tissue. To address these challenges, we have developed a series of perfluoropolyether (PFPE)-based hyperbranched (HBPFPE) nanoparticles with attached peptide aptamer as targeting ligands for specific in vivo detection of breast cancer with high 19F MRI sensitivity. A detailed comparison of the HBPFPE nanoparticles (NPs) with the previously reported trifluoroethyl acrylate (TFEA)-based polymers demonstrates that the mobility of fluorinated segments of the HBPFPE nanoparticles is significantly enhanced (19F T2 > 80 ms vs 31 ms), resulting in superior MR imaging sensitivity. Selective targeting was confirmed by auto- and pair correlation analysis of fluorescence microscopy data, in vitro immunofluorescence, in vivo19F MRI, ex vivo fluorescence and 19F NMR. The results highlight the high efficiency of aptamers for targeting and the excellent sensitivity of the PFPE moieties for 19F MRI. Of relevance to in vivo applications, the PFPE-based polymers exhibit much faster clearance from the body than the previously introduced perfluorocarbon emulsions (t1/2 ∼ 20 h vs up to months). Moreover, the aptamer-conjugated NPs show significantly higher tumor-penetration, demonstrating the potential of these imaging agents for therapeutic applications. This report of the synthesis of polymeric aptamer-conjugated PFPE-based 19F MRI CAs with high fluorine content (∼10 wt %) demonstrates that these NPs are exciting candidates for detecting diseases with high imaging sensitivity.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherAmerican Chemical Society (ACS Publications)
dc.relation.ispartofpagefrom9162
dc.relation.ispartofpageto9176
dc.relation.ispartofissue9
dc.relation.ispartofjournalACS Nano
dc.relation.ispartofvolume12
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchNanobiotechnology
dc.subject.fieldofresearchcode3211
dc.subject.fieldofresearchcode310607
dc.subject.keywordsScience & Technology
dc.subject.keywordsPhysical Sciences
dc.subject.keywordsChemistry, Multidisciplinary
dc.subject.keywordsChemistry, Physical
dc.titleHigh F-Content Perfluoropolyether-Based Nanoparticles for Targeted Detection of Breast Cancer by 19F Magnetic Resonance and Optical Imaging
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationZhang, C; Moonshi, SS; Wang, W; Hang, TT; Han, Y; Han, FY; Peng, H; Kral, P; Rolfe, BE; Gooding, JJ; Gaus, K; Whittaker, AK, High F-Content Perfluoropolyether-Based Nanoparticles for Targeted Detection of Breast Cancer by 19F Magnetic Resonance and Optical Imaging, ACS Nano, 2018, 12 (9), pp. 9162-9176
dc.date.updated2020-11-27T04:21:50Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyrightThis document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Nano, © 2018 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsnano.8b03726
gro.hasfulltextFull Text
gro.griffith.authorTa, Hang
gro.griffith.authorMoonshi, Shehzahdi S.


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