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  • Surface Modification Techniques for Endothelial Cell Seeding in PDMS Microfluidic Devices

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    Akther451119Published.pdf (503.8Kb)
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    Author(s)
    Akther, Fahima
    Yakob, Shazwani Binte
    Nguyen, Nam-Trung
    Ta, Hang T
    Griffith University Author(s)
    Ta, Hang
    Nguyen, Nam-Trung
    Year published
    2020
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    Abstract
    Microfluidic lab-on-a-chip cell culture techniques have been gaining popularity by offering the possibility of reducing the amount of samples and reagents and greater control over cellular microenvironment. Polydimethylsiloxane (PDMS) is the commonly used polymer for microfluidic cell culture devices because of the cheap and easy fabrication techniques, non-toxicity, biocompatibility, high gas permeability, and optical transparency. However, the intrinsic hydrophobic nature of PDMS makes cell seeding challenging when applied on PDMS surface. The hydrophobicity of the PDMS surface also allows the non-specific absorption/adsorption ...
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    Microfluidic lab-on-a-chip cell culture techniques have been gaining popularity by offering the possibility of reducing the amount of samples and reagents and greater control over cellular microenvironment. Polydimethylsiloxane (PDMS) is the commonly used polymer for microfluidic cell culture devices because of the cheap and easy fabrication techniques, non-toxicity, biocompatibility, high gas permeability, and optical transparency. However, the intrinsic hydrophobic nature of PDMS makes cell seeding challenging when applied on PDMS surface. The hydrophobicity of the PDMS surface also allows the non-specific absorption/adsorption of small molecules and biomolecules that might affect the cellular behaviour and functions. Hydrophilic modification of PDMS surface is indispensable for successful cell seeding. This review collates different techniques with their advantages and disadvantages that have been used to improve PDMS hydrophilicity to facilitate endothelial cells seeding in PDMS devices.
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    Journal Title
    Biosensors
    Volume
    10
    Issue
    11
    DOI
    https://doi.org/10.3390/bios10110182
    Copyright Statement
    © The Author(s), 2020. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Subject
    Analytical chemistry
    Biochemistry and cell biology
    PDMS
    endothelial cells
    hydrophobicity
    microfluidics
    surface treatment
    Publication URI
    http://hdl.handle.net/10072/399916
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    • Journal articles

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