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dc.contributor.authorZhong, Weien_US
dc.contributor.authorSkwarczynski, Mariuszen_US
dc.contributor.authorSimerska, Pavlaen_US
dc.contributor.authorF. Good, Michaelen_US
dc.contributor.authorToth, Istvanen_US
dc.date.accessioned2017-05-03T14:54:56Z
dc.date.available2017-05-03T14:54:56Z
dc.date.issued2009en_US
dc.identifier.issn14645416en_US
dc.identifier.doi10.1016/j.tet.2009.02.060en_US
dc.identifier.urihttp://hdl.handle.net/10072/39991
dc.description.abstractThe incorporation of lipid moieties into synthetic peptide vaccines has been demonstrated to self-adjuvant otherwise poorly immunogenic peptides, whereas carbohydrates have emerged to be advantageous carriers for assembling these peptides. With the advent of an efficient native chemical ligation method, which is compatible with both peptides and carbohydrates, we have developed highly pure self-adjuvanting tetravalent group A streptococcal vaccine candidates assembled on carbohydrate templates. The utility of chemoselective ligation has overcome difficulties in the synthesis and purification of branched high molecular weight peptides. Circular dichroism measurements provided the evidence of a-helix formation of the assembled peptide epitopes, which may have impact on their immunogenicity.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherPergamonen_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom3459en_US
dc.relation.ispartofpageto3464en_US
dc.relation.ispartofissue17en_US
dc.relation.ispartofjournalTetrahedronen_US
dc.relation.ispartofvolume65en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchOrganic Chemistry not elsewhere classifieden_US
dc.subject.fieldofresearchcode030599en_US
dc.titleDevelopment of highly pure α-helical lipoglycopeptides as self-adjuvanting vaccinesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2015-06-12T05:03:04Z
gro.hasfulltextNo Full Text


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