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dc.contributor.authorGhasem-Zadeh, Ali
dc.contributor.authorGalea, Mary P
dc.contributor.authorNunn, Andrew
dc.contributor.authorPanisset, Maya
dc.contributor.authorWang, Xiao-Fang
dc.contributor.authorIuliano, Sandra
dc.contributor.authorBoyd, Steven K
dc.contributor.authorForwood, Mark R
dc.contributor.authorSeeman, Ego
dc.date.accessioned2021-01-21T23:01:58Z
dc.date.available2021-01-21T23:01:58Z
dc.date.issued2020
dc.identifier.issn8756-3282en_US
dc.identifier.doi10.1016/j.bone.2020.115778en_US
dc.identifier.urihttp://hdl.handle.net/10072/399920
dc.description.abstractBACKGROUND: Modelling and remodelling adapt bone morphology to accommodate strains commonly encountered during loading. If strains exceed a threshold threatening fracture, modelling-based bone formation increases bone volume reducing these strains. If unloading reduces strains below a threshold that inhibits resorption, increased remodelling-based bone resorption reduces bone volume restoring strains, but at the price of compromised bone volume and microstructure. As weight-bearing regions are adapted to greater strains, we hypothesized that microstructural deterioration will be more severe than at regions commonly adapted to low strains following spinal cord injury. METHODS: We quantified distal tibial, fibula and radius volumetric bone mineral density (vBMD) using high-resolution peripheral quantitative computed tomography in 31 men, mean age 43.5 years (range 23.5-75.0), 12 with tetraplegia and 19 with paraplegia of 0.7 to 18.6 years duration, and 102 healthy age- and sex-matched controls. Differences in morphology relative to controls were expressed as standardized deviation (SD) scores (mean ± SD). Standardized between-region differences in vBMD were expressed as SDs (95% confidence intervals, CI). RESULTS: Relative to controls, men with tetraplegia had deficits in total vBMD of -1.72±1.38 SD at the distal tibia (p<0.001) and -0.68±0.69 SD at distal fibula (p=0.041), but not at the distal radius, despite paralysis. Deficits in men with paraplegia were -2.14±1.50 SD (p<0.001) at the distal tibia and -0.83±0.98 SD (p=0.005) at the distal fibula while distal radial total vBMD was 0.23±1.02 (p=0.371), not significantly increased, despite upper limb mobility. Comparing regions, in men with tetraplegia, distal tibial total vBMD was 1.04 SD (95%CI 0.07 , 2.01) lower than at the distal fibula (p=0.037) and 1.51 SD (95%CI 0.45, 2.57) lower than at the distal radius (p=0.007); the latter two sites did not differ from each other. Results were similar in men with paraplegia, but total vBMD at the distal fibula was 1.06 SD (95%CI 0.35, 1.77) lower than at the distal radius (p=0.004). CONCLUSION: Microarchitectural deterioration following spinal cord injury is heterogeneous, perhaps partly because strain thresholds regulating the cellular activity of mechano-transduction are region specific.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom115778en_US
dc.relation.ispartofjournalBoneen_US
dc.relation.ispartofvolume142en_US
dc.subject.fieldofresearchBiological Sciencesen_US
dc.subject.fieldofresearchEngineeringen_US
dc.subject.fieldofresearchMedical and Health Sciencesen_US
dc.subject.fieldofresearchcode06en_US
dc.subject.fieldofresearchcode09en_US
dc.subject.fieldofresearchcode11en_US
dc.subject.keywordsCortical Boneen_US
dc.subject.keywordsHR-pQCTen_US
dc.subject.keywordsMicrostructureen_US
dc.subject.keywordsParalysisen_US
dc.subject.keywordsSpinal Cord Injuryen_US
dc.titleHeterogeneity in Microstructural Deterioration Following Spinal Cord Injuryen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationGhasem-Zadeh, A; Galea, MP; Nunn, A; Panisset, M; Wang, X-F; Iuliano, S; Boyd, SK; Forwood, MR; Seeman, E, Heterogeneity in Microstructural Deterioration Following Spinal Cord Injury, Bone, 2020, 142, pp. 115778en_US
dcterms.dateAccepted2020-11-25
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.date.updated2020-12-03T22:32:10Z
dc.description.versionVersion of Record (VoR)en_US
gro.rights.copyright© 2020 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.en_US
gro.hasfulltextFull Text
gro.griffith.authorForwood, Mark R.


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