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  • Self-adjuvanting polyacrylic nanoparticulate delivery system for group A streptococcus (GAS) vaccine

    Author(s)
    Zaman, Mehfuz
    Skwarczynski, Mariusz
    Malcolm, Jessica M.
    Urbani, Carl N.
    Jia, Zhongfan
    Batzloff, Michael R.
    Good, Michael F.
    Monteiro, Michael J.
    Toth, Istvan
    Griffith University Author(s)
    Good, Michael F.
    Zaman, Mehfuz
    Year published
    2011
    Metadata
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    Abstract
    Infection with Streptococcus pyogenes, commonly known as group A Streptococcus (GAS), is responsible for acute and postinfectious complications, including rheumatic fever and rheumatic heart disease (RHD). RHD is a global health burden, and Australia's indigenous population has one of the highest incidences of RHD worldwide. A potential peptide (J14) vaccine candidate has been previously identified from the C-terminal region of the M protein. However, such peptide-based vaccine development is hampered by a lack of carriers and adjuvants suitable for humans use. We have developed a fully synthetic peptide subunit vaccine ...
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    Infection with Streptococcus pyogenes, commonly known as group A Streptococcus (GAS), is responsible for acute and postinfectious complications, including rheumatic fever and rheumatic heart disease (RHD). RHD is a global health burden, and Australia's indigenous population has one of the highest incidences of RHD worldwide. A potential peptide (J14) vaccine candidate has been previously identified from the C-terminal region of the M protein. However, such peptide-based vaccine development is hampered by a lack of carriers and adjuvants suitable for humans use. We have developed a fully synthetic peptide subunit vaccine candidate based on polyacrylate dendritic polymer. Intranasal administration of this nanoparticulate construct without additional adjuvant induced J14-specific IgG, which was also capable of in vitro opsonization of GAS, highlighting the potential of self-adjuvanting polyacrylate nanoparticle-based construct as a peptide vaccine delivery platform that may afford promising opportunities for treating systemic GAS infection.
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    Journal Title
    Nanomedicine: Nanotechnology, Biology and Medicine
    Volume
    7
    Issue
    2
    DOI
    https://doi.org/10.1016/j.nano.2010.10.002
    Subject
    Chemical sciences
    Biological sciences
    Other biological sciences not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/39994
    Collection
    • Journal articles

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    • Brisbane - Queensland, Australia
    First Peoples of Australia
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