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dc.contributor.authorZaman, Mehfuzen_US
dc.contributor.authorSkwarczynski, Mariuszen_US
dc.contributor.authorM. Malcolm, Jessicaen_US
dc.contributor.authorN. Urbani, Carlen_US
dc.contributor.authorJia, Zhongfanen_US
dc.contributor.authorR. Batzloff, Michaelen_US
dc.contributor.authorGood, Michaelen_US
dc.contributor.authorJ. Monteiro, Michaelen_US
dc.contributor.authorToth, Istvanen_US
dc.date.accessioned2017-05-03T14:54:59Z
dc.date.available2017-05-03T14:54:59Z
dc.date.issued2011en_US
dc.date.modified2013-09-25T22:43:25Z
dc.identifier.issn15499634en_US
dc.identifier.doi10.1016/j.nano.2010.10.002en_US
dc.identifier.urihttp://hdl.handle.net/10072/39994
dc.description.abstractInfection with Streptococcus pyogenes, commonly known as group A Streptococcus (GAS), is responsible for acute and postinfectious complications, including rheumatic fever and rheumatic heart disease (RHD). RHD is a global health burden, and Australia's indigenous population has one of the highest incidences of RHD worldwide. A potential peptide (J14) vaccine candidate has been previously identified from the C-terminal region of the M protein. However, such peptide-based vaccine development is hampered by a lack of carriers and adjuvants suitable for humans use. We have developed a fully synthetic peptide subunit vaccine candidate based on polyacrylate dendritic polymer. Intranasal administration of this nanoparticulate construct without additional adjuvant induced J14-specific IgG, which was also capable of in vitro opsonization of GAS, highlighting the potential of self-adjuvanting polyacrylate nanoparticle-based construct as a peptide vaccine delivery platform that may afford promising opportunities for treating systemic GAS infection.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom168en_US
dc.relation.ispartofpageto173en_US
dc.relation.ispartofissue2en_US
dc.relation.ispartofjournalNanomedicine: Nanotechnology, Biology and Medicineen_US
dc.relation.ispartofvolume7en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchBiological Sciences not elsewhere classifieden_US
dc.subject.fieldofresearchcode069999en_US
dc.titleSelf-adjuvanting polyacrylic nanoparticulate delivery system for group A streptococcus (GAS) vaccineen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2011
gro.hasfulltextNo Full Text


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