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dc.contributor.authorKhan Haleel, A
dc.contributor.authorMahendiran, D
dc.contributor.authorRafi, UM
dc.contributor.authorVeena, V
dc.contributor.authorShobana, S
dc.contributor.authorRahiman, AK
dc.date.accessioned2020-12-04T03:01:22Z
dc.date.available2020-12-04T03:01:22Z
dc.date.issued2018
dc.identifier.issn2470-1556
dc.identifier.doi10.1080/24701556.2019.1571514
dc.identifier.urihttp://hdl.handle.net/10072/399955
dc.description.abstractA series of mononuclear nickel(II), copper(II) and zinc(II) complexes of the type [ML1‒3Cl2] (1–9) have been synthesized and characterized. All the complexes interact with CT–DNA through groove mode of binding and bring about prominent nuclease activity on plasmid DNA. The complexes strongly inhibit the topoisomerase I, and also strongly interact with cyclin-dependent kinase receptor. The cytotoxicity activity were assessed aganist three human cancer cell lines such as lung (A549), cervical (HeLa) and colon (HCT–15), in which the complex 5 shows highest activity against the colon (HCT-15) cancer cell. The apoptotic studies were also reported.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherInforma UK Limited
dc.relation.ispartofpagefrom569
dc.relation.ispartofpageto582
dc.relation.ispartofissue12
dc.relation.ispartofjournalInorganic and Nano-Metal Chemistry
dc.relation.ispartofvolume48
dc.titleTetrazolo[1,5-a]pyrimidine-based metal(II) complexes as therapeutic agents: DNA interaction, targeting topoisomerase I and cyclin-dependent kinase studies
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationKhan Haleel, A; Mahendiran, D; Rafi, UM; Veena, V; Shobana, S; Rahiman, AK, Tetrazolo[1,5-a]pyrimidine-based metal(II) complexes as therapeutic agents: DNA interaction, targeting topoisomerase I and cyclin-dependent kinase studies, Inorganic and Nano-Metal Chemistry, 2018, 48 (12), pp. 569-582
dc.date.updated2020-12-04T03:00:25Z
gro.hasfulltextNo Full Text
gro.griffith.authorDharmasivam, Mahendiran


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