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dc.contributor.authorJ. Berners-Price, Susanen_US
dc.contributor.authorFilipovska, Aleksandraen_US
dc.date.accessioned2017-05-03T11:49:21Z
dc.date.available2017-05-03T11:49:21Z
dc.date.issued2008en_US
dc.date.modified2011-08-12T06:22:20Z
dc.identifier.issn00049425en_US
dc.identifier.doi10.1071/CH08175en_AU
dc.identifier.urihttp://hdl.handle.net/10072/39996
dc.description.abstractRecent developments in understanding the central place of mitochondria as regulators of programmed cell death have stimulated enormous interest in using them as targets for cancer chemotherapy. To overcome drug resistance and the lack of selectivity of cancer drugs in differentiating between normal and tumour cells, many strategies have been described in recent literature, including the use of delocalized lipophilic cations that selectively accumulate in tumour-cell mitochondria. Thioredoxin reductase, an enzyme involved in redox regulation and cell growth, has also emerged recently as an attractive drug target. Here we discuss the rationale for the design of lipophilic, cationic Au(i) phosphine complexes that are targeted to mitochondria of tumour cells and have potent and selective anticancer activity for cancer cells but not for normal cells. Our discovery that the thioredoxin system may be a critical target responsible for the selective toxicity provides a new strategy in the development of mitochondria-targeted chemotherapeutics.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherCSIRO Publishingen_US
dc.publisher.placeAustraliaen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom661en_US
dc.relation.ispartofpageto668en_US
dc.relation.ispartofissue9en_US
dc.relation.ispartofjournalAustralian Journal of Chemistryen_US
dc.relation.ispartofvolume61en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchInorganic Chemistry not elsewhere classifieden_US
dc.subject.fieldofresearchcode030299en_US
dc.titleThe Design of Gold-Based, Mitochondria-Targeted Chemotherapeuticsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2008
gro.hasfulltextNo Full Text


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