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dc.contributor.authorA. Herd, Karenen_US
dc.contributor.authorNelson, Michelleen_US
dc.contributor.authorMahalingam, Sureshen_US
dc.contributor.authorW. Tindle, Roberten_US
dc.date.accessioned2017-04-24T12:19:27Z
dc.date.available2017-04-24T12:19:27Z
dc.date.issued2010en_US
dc.date.modified2011-08-12T06:22:21Z
dc.identifier.issn00221317en_US
dc.identifier.doi10.1099/vir.0.015396-0en_AU
dc.identifier.urihttp://hdl.handle.net/10072/39997
dc.description.abstractHuman metapneumovirus (hMPV) is a major cause of upper and lower respiratory-tract infection in infants, the elderly and immunocompromised individuals. Virus-directed cellular immunity elicited by hMPV infection is poorly understood, in contrast to the phylogenetically and clinically related pathogen human respiratory syncytial virus (hRSV). In a murine model of acute lower respiratory-tract infection with hMPV, we demonstrate the accumulation of gamma interferon (IFN-?)-producing CD8+ T cells in the airways and lungs at day 7 post-infection (p.i.), associated with cytotoxic T lymphocytes (CTLs) directed to an epitope of the M2-1 protein. This CTL immunity was accompanied by increased pulmonary expression of Th1 cytokines IFN-? and interleukin (IL)-12 and antiviral cytokines (IFN-ߩ, as well as chemokines Mip-1a, Mip-1߬ Mig, IP-10 and CX3CL1. There was also a moderate increase in Th2-type cytokines IL-4 and IL-10 compared with uninfected mice. At 21 days p.i., a strong CTL response could be recalled from the spleen. A similar pattern of CTL induction to the homologous M2-1 CTL epitope of hRSV, and of cytokine/chemokine induction, was observed following infection with hRSV, highlighting similarities in the cellular immune response to the two related pathogens.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherSociety for General Microbiologyen_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom1302en_US
dc.relation.ispartofpageto1310en_US
dc.relation.ispartofissue5en_US
dc.relation.ispartofjournalJournal of General Virologyen_US
dc.relation.ispartofvolume91en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchMicrobiology not elsewhere classifieden_US
dc.subject.fieldofresearchcode060599en_US
dc.titlePulmonary infection of mice with human metapneumovirus induces local cytotoxic T-cell and immunoregulatory cytokine responses similar to those seen with human respiratory syncytial virusen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2010
gro.hasfulltextNo Full Text


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