• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Conference outputs
    • View Item
    • Home
    • Griffith Research Online
    • Conference outputs
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • Activatable magnetic resonance nanosensor as a potential imaging agent for detecting and discriminating thrombosis

    Author(s)
    Ta, Hang T
    Griffith University Author(s)
    Ta, Hang
    Year published
    2018
    Metadata
    Show full item record
    Abstract
    Objective: The early detection and accurate characterization of life-threatening diseases such as cardiovascular disease and cancer are critical to the design of treatment. Knowing whether or not a thrombus in a blood vessel is new (fresh) or old (constituted) is very important for physicians to decide a treatment protocol. Non-invasive differentiation between old and fresh thrombi would be of clinical importance to estimate the risk for embolization and the necessity of anticoagulation. Methods: We have designed smart MRI nano-sensors that can detect, sense and report the stage or progression of cardiovascular diseases ...
    View more >
    Objective: The early detection and accurate characterization of life-threatening diseases such as cardiovascular disease and cancer are critical to the design of treatment. Knowing whether or not a thrombus in a blood vessel is new (fresh) or old (constituted) is very important for physicians to decide a treatment protocol. Non-invasive differentiation between old and fresh thrombi would be of clinical importance to estimate the risk for embolization and the necessity of anticoagulation. Methods: We have designed smart MRI nano-sensors that can detect, sense and report the stage or progression of cardiovascular diseases such as thrombosis. The nanosensors were functionalized with fibrin-binding peptide to specifically target thrombus and were also labelled with fluorescence dye to enable optical imaging. Results: We have demonstrated that our nanosensors were able to switch between T1 and T2 signal depending on thrombus age or the presence or absence of thrombin at the thrombus site. The nano-sensor exhibits T2 effect in the absence of thrombin (dark signal), while it shows T1 effect in the presence of thrombin (bright signal). Since thrombin enzyme is only present in the fresh/new thrombi and absent in the old/aged ones, the nano-sensor is activated by thrombin and shows T1 effect on the fresh thrombi while it is non-activated and shows T2 effect on the old ones.The developed nanosensors appeared to be non-toxic when tested with Chinese Hamster Ovarian cells within the tested concentrations. Conclusions: Our data shows that these MRI nano-sensors are able to image and distinguish between fresh and old thrombi. This is a “one stop shopping” approach where a single imaging agent can be used to identify and classify thrombus throughout the body. The potential use of these nano-sensors is beyond cardiovascular disease and can also be applied for cancer detection.
    View less >
    Conference Title
    Atherosclerosis Supplements
    Volume
    32
    DOI
    https://doi.org/10.1016/j.atherosclerosissup.2018.04.482
    Subject
    Cardiovascular medicine and haematology
    Clinical sciences
    Science & Technology
    Life Sciences & Biomedicine
    Peripheral Vascular Disease
    Cardiovascular System & Cardiology
    Publication URI
    http://hdl.handle.net/10072/400083
    Collection
    • Conference outputs

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E
    • TEQSA: PRV12076

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander