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  • Liposomal doxorubicin as targeted delivery platform: Current trends in surface functionalization

    Author(s)
    Makwana, Vivek
    Karanjia, Jasmine
    Haselhorst, Thomas
    Anoopkumar-Dukie, Shailendra
    Rudrawar, Santosh
    Griffith University Author(s)
    Anoopkumar-Dukie, Shailendra
    Rudrawar, Santosh
    Haselhorst, Thomas E.
    Year published
    2020
    Metadata
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    Abstract
    Liposomal delivery systems have significantly enhanced the efficacy and safety of chemotherapeutic agents compared to free (non-liposomal) formulations. Liposomes are vesicles made up of lipophilic bilayer and a hydrophilic core which provides perfect opportunity for their application as transport vehicle for various therapeutic and diagnostic agents. Doxorubicin is the most exploited chemotherapeutic agent for evaluation of different liposomal applications, as its physicochemical properties permit high drug entrapment and easy remote loading in pre-formulated liposomes. Pegylated liposomal doxorubicin clinically approved ...
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    Liposomal delivery systems have significantly enhanced the efficacy and safety of chemotherapeutic agents compared to free (non-liposomal) formulations. Liposomes are vesicles made up of lipophilic bilayer and a hydrophilic core which provides perfect opportunity for their application as transport vehicle for various therapeutic and diagnostic agents. Doxorubicin is the most exploited chemotherapeutic agent for evaluation of different liposomal applications, as its physicochemical properties permit high drug entrapment and easy remote loading in pre-formulated liposomes. Pegylated liposomal doxorubicin clinically approved and, on the market, Doxil®, exemplifies the benefits offered upon the surface modification of liposome with polyethylene glycol. This unique formulation prolonged the drug residence time in the circulation and increased accumulation of doxorubicin in tumor tissue via passive targeting (enhanced permeability and retention effect). However, there is ample scope for further improvement in the efficiency of targeting tumors by coupling biological active ligands onto the liposome surface to generate intelligent drug delivery systems. Small biomolecules such as peptides, fraction of antibodies and carbohydrates have the potential to target receptors present on the surface of the malignant cells. Hence, active targeting of malignant cells using functionalised nanocarrier (liposomes encapsulated with doxorubicin) have been attempted which is reviewed in this article.
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    Journal Title
    International Journal of Pharmaceutics
    Volume
    593
    DOI
    https://doi.org/10.1016/j.ijpharm.2020.120117
    Subject
    Pharmacology and pharmaceutical sciences
    Doxorubicin
    Ligands
    Liposomes
    Surface Functionalization
    Targeted Drug Delivery Systems
    Publication URI
    http://hdl.handle.net/10072/400122
    Collection
    • Journal articles

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