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dc.contributor.authorCoombs, Geoffrey W
dc.contributor.authorDaley, Denise A
dc.contributor.authorThin, Yung
dc.contributor.authorPang, Stanley
dc.contributor.authorCollignon, Peter
dc.contributor.authorBradbury, Susan
dc.contributor.authorGottlieb, Thomas
dc.contributor.authorRobertson, Graham
dc.contributor.authorBranley, James
dc.contributor.authorBarbaro, Donna
dc.contributor.authorHuntington, Peter
dc.contributor.authorvan Hal, Sebastian
dc.contributor.authorBeukers, Alicia
dc.contributor.authorNimmo, Graeme
dc.contributor.authoret al.
dc.date.accessioned2020-12-11T03:46:39Z
dc.date.available2020-12-11T03:46:39Z
dc.date.issued2018
dc.identifier.issn0725-3141
dc.identifier.urihttp://hdl.handle.net/10072/400179
dc.description.abstractFrom 1st January to 31st December 2016, 32 institutions around Australia participated in the Australian Enterococcal Sepsis Outcome Programme (AESOP). The aim of AESOP 2016 was to determine the proportion of enterococcal bacteraemia isolates in Australia that were antimicrobial resistant, and to characterise the molecular epidemiology of the E. faecium isolates. Of the 1,058 unique episodes of bacteraemia investigated, 95.2% were caused by either E. faecalis (56.2%) or E. faecium (39.0%) Ampicillin resistance was detected in 0.2% of E. faecalis and in 91.5% of E. faecium. Vancomycin non-susceptibility was reported in 0.3% and 47.7% of E. faecalis and E. faecium respectively. Overall, 49.3% of E. faecium harboured vanA or vanB genes. For the vanA/B positive E. faecium isolates, 55.2% harboured vanB genes and 42.8% vanA genes, 2% harboured vanA and vanB genes. The percentage of E. faecium bacteraemia isolates resistant to vancomycin in Australia is significantly higher than that seen in most European countries. E. faecium consisted of 48 multilocus sequence types (STs) of which 90.2% of isolates were classified into 13 major STs containing 5 or more isolates. All major STs belong to clonal cluster (C) 17, a major hospital-adapted polyclonal E. faecium cluster. Four of the 6 predominant STs (ST17, ST796, ST80 and ST203) were found across most regions of Australia. The most predominant clone ST1421 (previously known as M-type 1) does not have a pstS housekeeping gene and was found in NSW, the ACT and Victoria. This clone was first described in ASSOP 2015. Overall, 74% of isolates belonging to the 6 predominant STs harboured vanA or vanB genes. The AESOP 2016 has shown enterococcal bacteraemias in Australia are frequently caused by polyclonal ampicillin-resistant high-level gentamicin resistant vanA or vanB E. faecium which have limited treatment options.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAustralian Government. Dept of Health & Ageing
dc.publisher.urihttps://www1.health.gov.au/internet/main/publishing.nsf/Content/cdi-2018-index
dc.relation.ispartofjournalCommunicable Diseases Intelligence
dc.relation.ispartofvolume42
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchHealth services and systems
dc.subject.fieldofresearchPublic health
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode4203
dc.subject.fieldofresearchcode4206
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsInfectious Diseases
dc.subject.keywordsAustralian Group on Antimicrobial Resistance (AGAR)
dc.subject.keywordsantimicrobial resistance surveillance
dc.titleAustralian Group on Antimicrobial Resistance (AGAR) Australian Enterococcal Sepsis Outcome Programme (AESOP) Annual Report 2016
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationCoombs, GW; Daley, DA; Thin, Y; Pang, S; Collignon, P; Bradbury, S; Gottlieb, T; Robertson, G; Branley, J; Barbaro, D; Huntington, P; van Hal, S; Beukers, A; Nimmo, G; et al., Australian Group on Antimicrobial Resistance (AGAR) Australian Enterococcal Sepsis Outcome Programme (AESOP) Annual Report 2016, Communicable Diseases Intelligence, 2018, 42
dc.date.updated2020-12-11T03:31:56Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2018 Australian Government. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorNimmo, Graeme R.


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