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dc.contributor.authorStatkievicz, Cristian
dc.contributor.authorToro, Luan Felipe
dc.contributor.authorde Mello-Neto, Joao Martins
dc.contributor.authorde Sa, Daniela Pereira
dc.contributor.authorCasatti, Claudio Aparecido
dc.contributor.authorMardegan Issa, Joao Paulo
dc.contributor.authorAngelo Cintra, Luciano Tavares
dc.contributor.authorde Almeida, Juliano Milanezi
dc.contributor.authorHitomi Nagata, Maria Jose
dc.contributor.authorGarcia, Valdir Gouveia
dc.contributor.authorTheodoro, Leticia Helena
dc.contributor.authorErvolino, Edilson
dc.description.abstractThe aim of this study was to evaluate the effects of photobiomodulation (PBM) with multiple sessions of low-level laser on the alveolar repair process of rats with major risk factors for medication-related osteonecrosis of the jaws (MRONJ). Senile rats received 0.45 mL of vehicle (VEH and VEH-PBM) or 0.45 mL of 100 μg/kg zoledronate (ZOL and ZOL-PBM) administrated intraperitoneally every two days during seven weeks. After three weeks of initiation of drug treatment the first lower left molar was extracted. No local treatment was performed in VEH and ZOL. VEH-PBM and ZOL-PBM were submitted to laser irradiation (660 ± 10 nm; 0.035 W; 2.1 J; 60 s) on the extraction site at 0, 2 and 4 days postoperatively. Euthanasia was performed 28 days after tooth extraction. Histological sections of the hemimandible were submitted to histopathological and histomorphometric analysis, as well as to histochemistry for collagen fiber maturation and immunohistochemistry for pro-inflammatory cytokines. In ZOL, general impairment of tissue repair, areas with osteonecrosis, lower newly formed bone tissue (NFBT), smaller amount of mature collagen fibers and increased immunoreactivity for TNFα, IL-1β and IL-6 were observed when compared to VEH and VEH-PBM. ZOL-PBM showed significant improvement in some parameters compared to ZOL, such as positive repair tissue, higher NFBT, greater amount of mature collagen fibers, besides TNFα and IL-1β immunoreactivity decrease. Zoledronate treatment severely compromised the tissue repair process of the tooth extraction site in rats with major risk factors for MRONJ. Based on parameters employed in the present study, PBM in multiple sessions can improve the alveolar repair process, constituting a promising preventive therapy to avoid the onset of post-extraction MRONJ.en_US
dc.relation.ispartofjournalJournal of Photochemistry and Photobiology B: Biologyen_US
dc.subject.fieldofresearchOther Physical Sciencesen_US
dc.subject.fieldofresearchBiochemistry and Cell Biologyen_US
dc.subject.keywordsScience & Technologyen_US
dc.subject.keywordsLife Sciences & Biomedicineen_US
dc.subject.keywordsMolecular Biology Biophysicsen_US
dc.titlePhotomodulation multiple sessions as a promising preventive therapy for medication-related osteonecrosis of the jaws after tooth extraction in ratsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationStatkievicz, C; Toro, LF; de Mello-Neto, JM; de Sa, DP; Casatti, CA; Mardegan Issa, JP; Angelo Cintra, LT; de Almeida, JM; Hitomi Nagata, MJ; Garcia, VG; Theodoro, LH; Ervolino, E, Photomodulation multiple sessions as a promising preventive therapy for medication-related osteonecrosis of the jaws after tooth extraction in rats, Journal of Photochemistry and Photobiology B: Biology, 2018, 184, pp. 7-17en_US
gro.hasfulltextNo Full Text
gro.griffith.authorMartins De Mello Neto, Joao M.

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