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dc.contributor.authorRinaldi, Simon
dc.contributor.authorDavies, Alexander
dc.contributor.authorFehmi, Janev
dc.contributor.authorBeadnall, Heidi N
dc.contributor.authorWang, Justine
dc.contributor.authorHardy, Todd A
dc.contributor.authorBarnett, Michael H
dc.contributor.authorBroadley, Simon A
dc.contributor.authorWaters, Patrick
dc.contributor.authorReddel, Stephen W
dc.contributor.authorIrani, Sarosh R
dc.contributor.authorBrilot, Fabienne
dc.contributor.authorDale, Russell C
dc.contributor.authorRamanathan, Sudarshini
dc.contributor.authorAustralian and New Zealand MOG Study Group
dc.date.accessioned2020-12-17T01:52:35Z
dc.date.available2020-12-17T01:52:35Z
dc.date.issued2021
dc.identifier.issn2332-7812
dc.identifier.doi10.1212/NXI.0000000000000924
dc.identifier.urihttp://hdl.handle.net/10072/400315
dc.description.abstractOBJECTIVE: Antibodies to myelin oligodendrocyte glycoprotein (MOG) are associated with CNS demyelination inclusive of optic neuritis (ON) and transverse myelitis (TM). To examine whether peripheral nervous system (PNS) involvement is associated with MOG antibody-associated disorders (MOGAD), we performed detailed characterization of an Australasian MOGAD cohort. METHODS: Using a live cell-based assay, we diagnosed 271 adults with MOGAD (2013-2018) and performed detailed clinical and immunologic characterization on those with likely PNS involvement. RESULTS: We identified 19 adults with MOGAD and PNS involvement without prior TM. All patients had CNS involvement including ON (bilateral [n = 3], unilateral [n = 3], and recurrent [n = 7]), a cortical lesion (n = 1), meningoencephalitis (n = 1), and subsequent TM (n = 4). Clinical phenotyping and neurophysiology were consistent with acute inflammatory demyelinating polyneuropathy (n = 1), myeloradiculitis (n = 3), multifocal motor neuropathy (n = 1), brachial neuritis (n = 2), migrant sensory neuritis (n = 3), and paresthesia and/or radicular limb pain (n = 10). Onset MRI spine was consistent with myeloradiculitis with nerve root enhancement in 3/19 and normal in 16/19. Immunotherapy resulted in partial/complete PNS symptom resolution in 12/15 (80%) (steroids and/or IV immunoglobulin n = 9, rituximab n = 2, and plasmapheresis n = 1). We identified serum antibodies targeting neurofascin 155, contactin-associated protein 2, or GM1 in 4/16 patients with MOGAD PNS compared with 0/30 controls (p = 0.01). There was no binding to novel cell surface antigens using an in vitro myelinating sensory neuronal coculture model. CONCLUSIONS: Myeloradiculitis, combined central and peripheral demyelination syndromes, and inflammatory neuropathies may be associated with MOGAD and may be immunotherapy responsive. We identified a subgroup who may have pathology mediated by coexistent autoantibodies.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherOvid Technologies (Wolters Kluwer Health)
dc.relation.ispartofpagefrome924
dc.relation.ispartofissue1
dc.relation.ispartofjournalNeurol Neuroimmunol Neuroinflamm
dc.relation.ispartofvolume8
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchcode3209
dc.titleOverlapping central and peripheral nervous system syndromes in MOG antibody-associated disorders
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationRinaldi, S; Davies, A; Fehmi, J; Beadnall, HN; Wang, J; Hardy, TA; Barnett, MH; Broadley, SA; Waters, P; Reddel, SW; Irani, SR; Brilot, F; Dale, RC; Ramanathan, S; Australian and New Zealand MOG Study Group, , Overlapping central and peripheral nervous system syndromes in MOG antibody-associated disorders., Neurol Neuroimmunol Neuroinflamm, 2021, 8 (1), pp. e924
dcterms.dateAccepted2020-10-16
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2020-12-17T01:37:58Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal
gro.hasfulltextFull Text
gro.griffith.authorBroadley, Simon


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