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dc.contributor.authorPatton, Austin H
dc.contributor.authorLawrance, Matthew F
dc.contributor.authorMargres, Mark J
dc.contributor.authorKozakiewicz, Christopher P
dc.contributor.authorHamede, Rodrigo
dc.contributor.authorRuiz-Aravena, Manuel
dc.contributor.authorHamilton, David G
dc.contributor.authorComte, Sebastien
dc.contributor.authorRicci, Lauren E
dc.contributor.authorTaylor, Robyn L
dc.contributor.authorStadler, Tanja
dc.contributor.authorLeaché, Adam
dc.contributor.authorMcCallum, Hamish
dc.contributor.authorJones, Menna E
dc.contributor.authoret al.
dc.date.accessioned2020-12-21T04:38:31Z
dc.date.available2020-12-21T04:38:31Z
dc.date.issued2020
dc.identifier.issn0036-8075
dc.identifier.doi10.1126/science.abb9772
dc.identifier.urihttp://hdl.handle.net/10072/400447
dc.description.abstractEmerging infectious diseases pose one of the greatest threats to human health and biodiversity. Phylodynamics is often used to infer epidemiological parameters essential for guiding intervention strategies for human viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2). Here, we applied phylodynamics to elucidate the epidemiological dynamics of Tasmanian devil facial tumor disease (DFTD), a fatal, transmissible cancer with a genome thousands of times larger than that of any virus. Despite prior predictions of devil extinction, transmission rates have declined precipitously from ~3.5 secondary infections per infected individual to ~1 at present. Thus, DFTD appears to be transitioning from emergence to endemism, lending hope for the continued survival of the endangered Tasmanian devil. More generally, our study demonstrates a new phylodynamic analytical framework that can be applied to virtually any pathogen.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Association for the Advancement of Science (AAAS)
dc.relation.ispartofpagefromeabb9772
dc.relation.ispartofissue6522
dc.relation.ispartofjournalScience
dc.relation.ispartofvolume370
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchcode31
dc.titleA transmissible cancer shifts from emergence to endemism in Tasmanian devils
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationPatton, AH; Lawrance, MF; Margres, MJ; Kozakiewicz, CP; Hamede, R; Ruiz-Aravena, M; Hamilton, DG; Comte, S; Ricci, LE; Taylor, RL; Stadler, T; Leaché, A; McCallum, H; Jones, ME; et al., A transmissible cancer shifts from emergence to endemism in Tasmanian devils., Science, 2020, 370 (6522), pp. eabb9772
dcterms.dateAccepted2020-10-21
dc.date.updated2020-12-21T04:19:54Z
gro.hasfulltextNo Full Text
gro.griffith.authorMcCallum, Hamish


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